RICHARD S BOCKMAN, MD
Osteopathic Medicine at 70 St, New York, NY

5556645, Sep 17, 1996

Apr 26, 1995

8/430142

Richard Bockman - New York NY
Peter Guidon - Union NJ

A61K 3324, A61K 3128

424650

Skin, connective and support tissue repair is enhanced and augmented by administering pharmaceutically acceptable gallium-containing compounds in amounts sufficient to provide therapeutic levels of elemental gallium. Gallium-containing compounds mimic the effects of endogenous growth factors to induce cells within these tissues to produce new matrix by increasing the formation of critical structural matrix proteins responsible for skin, support and connective tissue repair, maintenance and augmentation. Gallium-containing compounds are suitable for a variety of applications in wound healing, including dermatologic and cosmetic skin repair, bone fracture repair and successful bonding of implanted tissue grafts and connective and support tissue prostheses. The unique ability of the gallium-containing compounds to increase new matrix component formation and favorably alter the proliferation of specific cell types needed for tissue repair is separate and distinct from gallium's inhibitory activity on matrix-resorbing cells such as bone-resorbing osteoclasts.

6287606, Sep 11, 2001

Aug 7, 1997

8/908659

Richard Bockman - New York NY
Peter Guidon - Cranford NJ

A01M 5916

424650

Tissue and organ repair, healing and augmentation are enhanced by administering pharmaceutically acceptable group IIIa element-containing compounds in amounts sufficient to provide therapeutic levels of the elements. Group IIIa element-containing compounds mimic the beneficial biological effects of endogenous growth factors to induce cells responsible for repair, healing and augmentation of tissues and organs. Group IIIa element-containing compounds are suitable for a variety of applications such as wound healing, bone fracture repair, treatment of dermatologic conditions and successful bonding of implanted tissue grafts and prostheses.

6165514, Dec 26, 2000

Dec 29, 1998

9/222755

Richard Bockman - New York NY
Peter Guidon - Cranford NJ

The Hospital for Special Surgery - New York NY

A61K 950, A61K 3324, A61K 3128

424495

Tissue and organ repair, healing and augmentation are enhanced by administering pharmaceutically acceptable group IIIa element-containing compounds in amounts sufficient to provide therapeutic levels of the elements. Group IIIa element-containing compounds mimic the beneficial biological effects of endogenous growth factors to induce cells responsible for repair, healing and augmentation of tissues and organs. Group IIIa element-containing compounds are suitable for a variety of applications such as wound healing, bone fracture repair, treatment of dermatologic conditions and successful bonding of implanted tissue grafts and prostheses.

4686104, Aug 11, 1987

Apr 22, 1986

6/853144

Richard S. Bockman - New York NY
Raymond P. Warrell - New York NY

Sloan-Kettering Institute for Cancer Research - New York NY

A61K 3324, A61K 3128

424131

Metal-containing compounds have been found to decrease calcium resorption from bone. These compounds, when administered to patients who are suffering from diseases characterized by accelerated bone resorption, impede the flow of bone calcium into the blood and increase the calcium content of bone tissue.

4529593, Jul 16, 1985

Jun 20, 1984

6/622726

Raymond P. Warrell - New York NY
Richard S. Bockman - New York NY

Sloan-Kettering Institute for Cancer Research - New York NY

A61K 3300

424127

The present invention comprises a method of preventing or treating a disorder associated with accelerated loss of calcium from bone in a human individual comprising administering to the individual a pharmaceutically acceptable gallium compound. Of especial importance among the disorders which may be thus prevented or treated are hypercalcemia, accelerated bone loss associated with osteopenia, osteoporosis, bone metastasis due to malignant tumors, and hyperparathyroidism. In the method of the present invention gallium compounds may be administered by any and all routes. Although all biocompatible, soluble compounds of gallium may be used in the present invention, gallium nitrate is preferred, most preferably in a pharmaceutically acceptable carrier.

5686116, Nov 11, 1997

Jun 5, 1995

8/461724

Richard Bockman - New York NY
Peter Guidon - Cranford NJ

New York Society For The Relief Of The Ruptured and Crippled,
Maintaining The Hospital for Special Surgery - New York NY

A61K 3324, A61K 3816, A61K 3128

424650

Tissue and organ repair, healing and augmentation are enhanced by administering pharmaceutically acceptable group IIIa element-containing compounds in amounts sufficient to provide therapeutic levels of the elements. Group IIIa element-containing compounds mimic the beneficial biological effects of endogenous growth factors to induce cells responsible for repair, healing and augmentation of tissues and organs. Group IIIa element-containing compounds are suitable for a variety of applications such as wound healing, bone fracture repair, treatment of dermatologic conditions and successful bonding of implanted tissue grafts and prostheses.

4704277, Nov 3, 1987

Apr 30, 1985

6/729057

Richard S. Bockman - New York NY
Raymond P. Warrell - New York NY

Sloan-Kettering Institute for Cancer Research - New York NY

A61F 3324

424131

Metal containing compounds have been found which increase bone growth, decrease hydroxyapatite solubility, increase the size and/or the perfection of hydroxyapatite crystals in bone, and increase the tensile strength of bone. These compounds, when administered to patients who are suffering from diseases characterized by bone resorption impede the flow of bone calcium into the blood, and encourage the growth of new, normal bone tissue.