Inventors:
Richard A. Rubin - Pittsburgh PA
Kenneth A. Giuliano - Pittsburgh PA
Albert H. Gough - Glenshaw PA
R. Terry Dunlay - New Kensington PA
Assignee:
Cellomics, Inc. - Pittsburgh PA
International Classification:
G01N 33533
US Classification:
435 72, 435 721, 435 29, 435 4051, 435 5, 435 71, 435174, 435325, 4352831, 436172, 436546, 436800, 436809, 436501
Abstract:
The present invention provides systems, methods, and screens to measure receptor internalization in a single step with appropriate automation and throughput. This approach involves luminescent labeling of the receptor of interest and the automated measurement of receptor internalization to a perinuclear location.