Inventors:
Susan E. Bates - Bethesda MD, US
Antonio Tito Fojo - Rockville MD, US
Richard L. Piekarz - Silver Spring MD, US
John J. Wright - Falls Church VA, US
George J. Grimes - Rockville MD, US
Karen M. Schweikart - Centreville VA, US
Assignee:
Government of the United of America, Represented by the Secretary, Department of Health and.... - Rockville MD
International Classification:
A61K 38/02, A61K 39/395, A61K 38/07, A61K 31/165, A61P 35/00
US Classification:
4241301, 514 2, 514 18, 514646
Abstract:
Disclosed are topical compositions comprising at least one histone deacetylase (HDAC) inhibitor (HDI) and a carrier comprising petrolatum. Methods for using such compositions to treat or inhibit cancer and various skin diseases are also disclosed.