RICHARD PAUL JUNGHANS
Physician in Providence, RI
License number
Rhode Island MD11666
Issued Date
Aug 12, 2004
Expiration Date
6, 2016
Category
Physician
Type
Allopathic Physician (MD)
Address
Address
Providence, RI
Education
University of Miami School of Medicine, Mar 6, 1983
Professional information
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Richard Junghans, Providence RI
Richard Junghans, Providence RI
Work:
Roger Williams Hospital
825 Chalkstone Ave, Providence, RI 02908
825 Chalkstone Ave, Providence, RI 02908
Viral Vectors Encoding Multiple Highly Homologus Non-Viral Polypeptides And The Use Of Same
Viral Vectors Encoding Multiple Highly Homologus Non-Viral Polypeptides And The Use Of Same
US Patent:
2012013, May 31, 2012
Filed:
Jan 22, 2010
Appl. No.:
13/145488
Inventors:
Wen Yang - Sharon MA, US
Richard P. Junghans - Providence RI, US
Anthony J. Bais - Providence RI, US
Richard P. Junghans - Providence RI, US
Anthony J. Bais - Providence RI, US
International Classification:
A61K 35/76, A61P 35/00, C12N 5/10, A61P 31/12, A61P 31/18, A61K 35/14, C12N 15/63, A61P 31/00
US Classification:
424 9321, 4353201, 424 932, 435325, 435348
Abstract:
The present invention relates to compositions and methods for creation of vector nucleic acid sequences (e.g., retroviral nucleic acid sequences) that comprise two or more exogenous nucleic acid sequences that encode highly homologous (e.g., identical) polypeptide sequences, yet wherein at least one of the exogenous nucleic acid sequences has been mutated using degenerate codons for purpose of reducing homology between the two or more exogenous nucleic acid sequences while maintaining the encoded polypeptide sequence. Preferred nucleic acid sequences include those encoding multi-chimeric immune receptor (CIR) genes. Specific nucleic acid sequences of such CIR genes are also disclosed.