Inventors:
Raymond L. White - Salt Lake City UT
Richard M. Cawthon - Salt Lake City UT
Ying Li - Salt Lake City UT
Assignee:
University of Utah Research Foundation - Salt Lake City UT
International Classification:
C12Q 168, C12P 1934, C07H 2104, C12N 1500
Abstract:
The present invention is directed to somatic mutations of the NF1 gene which are found in human tumors. In addition, the present invention is directed to methods of screening humans to determine those having somatic mutations in the NF1 gene in tumors. Finally, the invention is directed to a method of treating a human having a tumor with a somatic mutation in the NF1 gene by restoring natural regulation of ras proteins.