RICHARD LIN
Broker in Boston, MA
License number
Massachusetts 9536299
Issued Date
Apr 25, 2015
Expiration Date
Nov 25, 2017
Type
Salesperson
Address
Address
Boston, MA 02109
Professional information
Richard Lin
Location:
Greater Boston Area
Industry:
Medical Practice
Methods For Treating Mitf-Related Disorders
US Patent:
2009017, Jul 9, 2009
Filed:
Oct 10, 2006
Appl. No.:
12/089975
Inventors:
David E. Fisher - Newton MA, US
Richard Lin - Boston MA, US
Richard Lin - Boston MA, US
International Classification:
A61K 31/7105, C12Q 1/26, G01N 33/53, A61P 35/00
US Classification:
514 44, 435 25, 435 71
Abstract:
Methods for treating melanoma and other MITF-related disorders by administering a compound that causes an increase in HIF-1 level or activity (e.g., by increasing the level of HIF-1I in a cell) within cells. Such methods include administration of a compound that is a hydroxylase inhibitor, e.g., a prolyl hydroxylase inhibitor that reduces hydroxylation of HIF-1I thereby causing an increase in HIF-1I in the cell. Such treatment can lead to a decrease in MITF activity or expression.