RICHARD LARSON, MD
Medical Practice in Albuquerque, NM

6630447, Oct 7, 2003

Jan 16, 2001

09/760599

Richard S. Larson - Albuquerque NM

University of New Mexico - Albuquerque NM

A61K 3800

514 11, 530317, 530321

Cyclic peptides inhibit LFA-1 interaction with ICAM-1 and are useful in treatment of hematopoietic neoplasms and in adjunct therapy in prevention of retinoic acid syndrome and diseases involving emigration of leukocytes into organ tissue.

6649592, Nov 18, 2003

Jan 14, 2000

09/483550

Richard S. Larson - Albuquerque NM

Science Technology Corporation UNM - Albuquerque NM

C07K 1400

514 9, 530300

Cyclic peptides inhibit LFA-1 interaction with ICAM-1 and are useful in treatment of hematopoietic neoplasms and in adjunct therapy in prevention of retinoic acid syndrome and diseases involving emigration of leukocytes into organ tissue.

2011005, Mar 3, 2011

Feb 8, 2008

12/069284

Richard S. Larson - Albuquerque NM, US
Brian Hjelle - Placitas NM, US
Pam R. Hall - Albuquerque NM, US
David C. Brown - Albuquerque NM, US
Marco Bisoffi - Albuquerque NM, US
Susan M. Brozik - Albuquerque NM, US
Darren W. Branch - Albuquerque NM, US
Thayne L. Edwards - Albuquerque NM, US
David Wheeler - Albuquerque NM, US

C12Q 1/70, G01N 33/53, C12M 1/34

435 5, 422 69, 436501, 435 72, 4352872

Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge with respect to sensitivity, specificity, and selectivity. Ideally, assays for accurate and real time detection of viral agents and other bioagents would not necessitate any pre-processing of the analyte, which would make them applicable for example to bodily fluids (blood, sputum) and man-made as well as naturally occurring bodies of water (pools, rivers). We describe herein a robust biosensor that combines the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents. In preferred embodiments, a lithium tantalate based SAW transducer with silicon dioxide waveguide sensor platform featuring three test and one reference delay lines was used to adsorb antibodies directed against Coxsackie virus B4 or the negative-stranded category A bioagent Sin Nombre virus (SNV), a member of the genus Hantavirus, family Bunyaviridae, negative-stranded RNA viruses. Rapid detection (within seconds) of increasing concentrations of viral particles was linear over a range of order of magnitude for both viruses, although the sensor was approximately 50×10-fold more sensitive for the detection of SNV. For both pathogens, the sensor's selectivity for its target was not compromised by the presence of confounding Herpes Simplex virus type 1. The biosensor was able to detect SNV at doses lower than the load of virus typically found in a human patient suffering from hantavirus cardiopulmonary syndrome (HCPS). Further, in a proof-of-principle real world application, the SAW biosensor was capable of selectively detecting SNV agents in complex solutions, such as naturally occurring bodies of water (river, sewage effluent) without analyte pre-processing.

2009020, Aug 20, 2009

Nov 28, 2008

12/315132

Richard S. Larson - Albuquerque NM, US
Larry A. Sklar - Albuquerque NM, US
Bruce S. Edwards - Albuquerque NM, US
Tudor I. Oprea - Albuquerque NM, US
Debbie M. Lovato - Albuquerque NM, US
Hadya M. Khawaja - Albuquerque NM, US
Stuart S. Winter - Albuquerque NM, US
Susan M. Young - Albuquerque NM, US

STC. UNM - Albuquerque NM

A61K 38/13, A61K 33/24, A61K 39/395, A61K 31/57, G01N 33/50, A61P 35/00

4241331, 514 11, 424649, 514179, 435 4051

Compounds disclosed which inhibit ABCB1 transporter protein are useful for treating diseases in which ABCB1 transporter protein mediates the disease state, including numerous cancers, including hematopoietic cancers, including various leukemias, especially T-lineage acute lymphoblastic leukemia, as well as cancerous tumors, especially forms which exhibit multiple drug resistance. Pharmaceutical compositions which comprise an inhibitor of ABCB1 transporter protein and at least one additional anticancer agent, optionally in combination with a pharmaceutically acceptable carrier, additive or excipient are another aspect of the present invention. A flow cytometry based, high-throughput screening (HST) assay that quantifies ABCB1 efflux is also disclosed. Methods of identifying inhibitors of ABCB1, ABCG2 and ABCC1 transporter proteins are also disclosed.

2013021, Aug 22, 2013

Apr 1, 2013

13/854560

Richard S. Larson - Albuquerque NM, US

C07F 9/94, C07F 5/00, A61K 51/04

424 165, 540145, 534 16

The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probe is capable of detecting precancerous cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of NHL. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

6881747, Apr 19, 2005

May 5, 2003

10/429041

Richard S. Larson - Albuquerque NM, US
Carston R. Wagner - St. Paul MN, US

Science & Technology Corporation @UNM - Albuquerque NM
Regents of the University of Minnesota - Minneapolis MN

A61K031/4166, C07D233/02

514386, 5483171, 5483195

The present invention provides a compound and a method of making a compound according to the following formula: where Ris an alkyl group having 1 to 12 carbons; Ris a urea group; Ris an active group, such as fluorescein, a toxin, radiolabel or drug; and R, Rand Rare each independently a halide group.