Inventors:
Bin Tean Teh - Grand Rapids MI, US
Kyle Furge - Kalamazoo MI, US
Dan Huang - Ada MI, US
Richard Kahnoski - Grand Rapids MI, US
International Classification:
A61K 31/404, A61P 35/00, A61K 39/395, A61K 31/7088, G01N 33/53, C12Q 1/68
US Classification:
4241581, 514414, 514 44 A, 435 71, 435 6
Abstract:
A method of determining whether a tumor will be non-responsive to sunitinib therapy including detecting whether IL-8 or MMP12 expression levels in the tumor are elevated as compared to a control, that is, a tumor having elevated IL-8 or MMP12 levels will be non-responsive to sunitinib. Also, a method for inhibiting the proliferation or causing the death of a sunitinib-resistant tumor cell by contacting the cell with an agent that inhibits IL-8 or MMP12 activity and with sunitinib, whereby proliferation of the tumor cell is inhibited or the tumor cell dies. Further, the invention includes compositions and kits that include an IL-8 inhibitor or an MMP12 inhibitor and sunitinib, and related methods of treatment.