Inventors:
Dale Kempf - Libertyville IL, US
Richard Bertz - Kenosha WI, US
Jeffrey Waring - Franklin WI, US
International Classification:
A61K031/7056
Abstract:
The present invention is directed to a method for inducing UGT1A1 isoform expression for treatment of a disease, disorder or adverse effect caused by an elevated serum concentration of an UGT1A1 substrate comprising the step of administering to a subject an effective amount of ritonavir. In particular, the present invention is directed to a method of treating unconjugated hyperbilirubinemia by UGT1A1 induction comprising the step of administering to a subject an effective amount of ritonavir.