Inventors:
George Kuchel - Avon CT, US
Richard Bucala - New Haven CT, US
International Classification:
A61K 31/42, A61K 31/70, A61K 38/02, A61K 39/395, A61P 13/00, C07H 21/02, C12Q 1/68
US Classification:
424130100, 514002000, 514378000, 514043000, 536024100
Abstract:
The invention relates generally to methods for treating and/or preventing bladder disorders. In certain embodiments the invention comprises methods for the treatment and/or prevention of a bladder disorder comprising administering an effective amount of a therapeutic agent that decreases the expression, release or biological activity of macrophage migration inhibition factor (MIF) to a subject in need thereof. In other aspects the invention relates to a method for diagnosing bladder disease and/or bladder disease severity comprising screening for a MIF gene or MIF receptor gene polymorphism or expression level.