Inventors:
Richard Smith - Belmont CA, US
Alice Bakker - Cupertino CA, US
Amy N. Duguay - Saratoga CA, US
Peng Li - San Francisco CA, US
Yang Li - Mountain View CA, US
Assignee:
AMGEN INC. - Thousand Oaks CA
International Classification:
A61K 39/395, C07K 14/00, C07K 16/00, C07H 21/00, A61K 38/18, A61P 3/00, C12N 15/63, C12N 5/10, C12P 21/06
US Classification:
4241581, 530324, 530363, 5303891, 536 232, 536 2353, 514 91, 4353201, 435325, 435 691
Abstract:
Binding proteins that specifically bind to β-Klotho or portions thereof, FGFR1c or portions thereof, or both FGFR1c and β-Klotho, and optionally other proteins as well are provided. Coding sequences, methods of treatment and pharmaceutical compositions are also provided.