RICHARD J KRAUSE
Engineers in Perkasie, PA
License number
Pennsylvania PE017022E
Category
Engineers
Type
Professional Engineer
Address
Address
Perkasie, PA 18944
Professional information
Disposable Reciprocating Bag Mixing Systems
US Patent:
2005024, Nov 10, 2005
Filed:
May 4, 2004
Appl. No.:
10/838576
Inventors:
Richard Krause - Perkasie PA, US
International Classification:
B01F011/00
US Classification:
366332000
Abstract:
A (disposable) single-use closed mixing system consisting of a mixing impeller(s) on a shaft, the shaft being sealed to the top of the bag. The flexible bag is used as the reciprocating membrane. Bag sizes 1 to 10,000 liters, can be gamma sterilized or non-sterile. The bags can be round or square in shape. All components including the impeller, shaft and accessories are CLASS VI material. The impeller or impellers used for large bags can be round, or square with holes, flutes, fins, tubing or a combination of these to meet specific mixing requirements. A detachable electric or air powered actuator provides the reciprocating action. The impeller shaft is sealed to the bag eliminating the need for rotary seals. Disposal of the mixing system is environmentally friendly.
Optical Probe Mounting Device
US Patent:
4803365, Feb 7, 1989
Filed:
May 8, 1987
Appl. No.:
7/047850
Inventors:
Richard J. Krause - Perkasie PA
Jaw F. Lee - Newtown Sq. PA
Craig W. Breckenridge - Allentown PA
Jaw F. Lee - Newtown Sq. PA
Craig W. Breckenridge - Allentown PA
Assignee:
BioChem Technology - Malvern PA
International Classification:
G01N 2164
US Classification:
2504612
Abstract:
An optical probe mounting device for the insertion end of a fluorescence measuring optical probe which facilitates mounting on a biological reactor vessel window fitting. The device consists of a rigid hollow cylinder sized to closely receive the probe and to closely slide within the interior of the fitting. A quartz window seals the insertion end of the cylinder to allow passage of ultraviolet light without attenuation. A flange is sealingly affixed to the cylinder which permits the cylinder to extend a predetermined distance into the vessel. An O-ring extends around the cylinder or a face seal is used on the rear flange of the well, thereby providing a seal upon insertion of the device into the fitting.
Biobag Undulating Mixing System
US Patent:
2005006, Mar 24, 2005
Filed:
Sep 20, 2004
Appl. No.:
10/945345
Inventors:
Richard Krause - Perkasie PA, US
International Classification:
B01F011/00
US Classification:
366111000, 366208000, 366218000
Abstract:
A multiple single-use bag mixing system utilizing lifting one end of the bag at a harmonic frequency determined by the viscosity of the fluids and bag dimensions. The bags are positioned on stationary racks with UV or white light source positioned over each bag were required. The degree of energy efficient gentile mixing is determine by a variable speed drive moving the ends of all the bags simultaneously on the racks.
Single-Use Biobags With Sendors: Do, Ph, Co2 And Temperature
US Patent:
2005016, Jul 28, 2005
Filed:
Jan 24, 2005
Appl. No.:
11/040702
Inventors:
Richard Krause - Perkasie PA, US
International Classification:
B01L003/00
US Classification:
422102000, 422056000
Abstract:
A single-use biobag provided with at least two none invasive florescent-optical sensors. The sterile sensors inside the biobag secured by an adhesive backing or secured by a CLASS VI fitting assures the sterile environment of the fluids in the bags. The sensors detectors are located outside the bag and secured in a position to align the sensors with the detectors. Either Velcro on the detector and outside of the bag has been used for sensor/detector alignment or the detector is mounted on the containment vessel and biobag straps are used to assure position of the bag for sensor/detector alignment. The process variables to be measured by the fluorescent optical disposable sensors are: DO, pH, COand temperature. The biobag film is CLASS VI material and should be optically clear and free of interfering florescent compounds.