RICHARD J. BABAIAN, M.D.
Urology at Holcombe Blvd, Houston, TX
License number
Texas F4747
Category
Radiology
Type
Urology
Address
Address
1515 Holcombe Blvd, Houston, TX 77030
Phone
(713) 792-6161
(713) 792-2991
(713) 792-2991
Personal information
See more information about RICHARD J. BABAIAN at radaris.comName
Address
Phone
1515 Holcombe Blvd, Houston, TX 77030
2801 Rice Blvd, Houston, TX 77005
2801 Rice Ave, Houston, TX 77005
Professional information
Unique Protein Marker For Bladder Cancer
US Patent:
5221612, Jun 22, 1993
Filed:
Mar 3, 1989
Appl. No.:
7/318790
Inventors:
Haiyen E. Zhau - Houston TX
Richard J. Babaian - Houston TX
Richard J. Babaian - Houston TX
Assignee:
Board of Regents, The University of Texas System - Austin TX
International Classification:
G01N 33538
US Classification:
435 792
Abstract:
The present invention involves a method for detecting bladder cancer in a subject. The method preferably comprises first collecting a urine sample from the subject. The presence of a proteinaceous substance having a molecular weight of about 180 kDa according to its relative electrophoretic migration rate through detergent-containing polyacrylamide gel is then measured. This substance reversibly binds concanavalin A and is complexed with gamma globulin while in the urine. The gamma globulin complex binds to Staphlococcal protein A. Said proteinaceous substance, when present in detectable amount, is an indicator of bladder cancer.
The method of the present invention for diagnosing bladder cancer in a subject may also be described as comprising detection in a urine sample from said subject of a proteinaceous substance having a molecular weight of about 180 kDa and being unreactive with antibodies specifically binding to carcinoembryonic antigen or epidermal growth factor receptor. When an antibody is used for the present method of diagnosis, an initial step for preparing an antibody specifically binding a urinary 180 kDa antigen present in urine of bladder cancer victims is carried out. This antibody of course may be prepared by others and merely obtained by commercial purchase.
Unique Protein Marker For Bladder Cancer
US Patent:
5359031, Oct 25, 1994
Filed:
Apr 28, 1992
Appl. No.:
7/875626
Inventors:
Haiyen E. Zhau - Houston TX
Richard J. Babaian - Houston TX
Richard J. Babaian - Houston TX
Assignee:
Board of Regents, The University of Texas System - Austin TX
International Classification:
C07K 1500
US Classification:
530350
Abstract:
The present invention involves a method for detecting bladder cancer in a subject. The method preferably comprises first collecting a urine sample from the subject. The presence of a proteinaceous substance having a molecular weight of about 180 kDa according to its relative electrophoretic migration rate through detergent-containing polyacrylamide gel is then measured. This substance reversibly binds concanavalin A and is complexed with gamma globulin while in the urine. The gamma globulin complex binds to Staphlococcal protein A. Said proteinaceous substance, when present in detectable amount, is an indicator of bladder cancer.
Richard J Babaian, Houston TX
Specialties:
Urologist
Address:
1515 Holcombe Blvd, Houston, TX 77030
Education:
Georgetown University, School of Medicine - Doctor of Medicine
University of Texas-M.D. Anderson Cancer Center - Fellowship - Urologic Oncology
University of Texas-M.D. Anderson Cancer Center - Fellowship - Urologic Oncology
Board certifications:
American Board of Urology Certification in Urology
Richard Joseph Babaian, Houston TX
Specialties:
Urology, Surgery
Work:
Md Anderson Cancer Ctr Surgery
1515 Holcombe Blvd, Houston, TX 77030
1515 Holcombe Blvd, Houston, TX 77030
Education:
Georgetown University (1972)
Serum Dna Methylation Screening For Cancer
US Patent:
2010009, Apr 22, 2010
Filed:
Jul 30, 2007
Appl. No.:
12/376148
Inventors:
Richard Babaian - Houston TX, US
Herbert Fritsche - Houston TX, US
Li-Ying Yang - Bellaire TX, US
Herbert Fritsche - Houston TX, US
Li-Ying Yang - Bellaire TX, US
International Classification:
C12Q 1/68
US Classification:
435 6
Abstract:
We disclose a method of screening a mammal for a cancer associated with methylation of promoters of tumor-suppressor genes by collecting a sample of a body fluid or tissue of the mammal containing free DNA; isolating the free DNA from the sample; amplifying at least a portion of the promoter of each of a plurality of turner-suppressor genes associated with the cancer from the free DNA, to yield a plurality of amplified promoters; and quantifying methylation of each of the plurality of amplified promoters, to yield a methylation quantity. The method can have a high sensitivity and high specificity and can thus reduce the proportion of unneeded biopsies. It can also be performed with minimal invasiveness and discomfort to a patient.