Inventors:
Michael P. Lisanti - Philadelphia PA, US
Federica Sotgia - Philadelphia PA, US
Richard G. Pestell - Philadelphia PA, US
International Classification:
C40B 30/04, C40B 40/10, G01N 21/64, G01N 33/566, C12Q 1/68
US Classification:
506 9, 435 71, 435 612, 435 792, 506 18
Abstract:
The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of, for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate, bladder, epithelial, non-epithelial, lymphomas, sarcomas, melanomas, and the like, wherein the method comprises determining the level of expression o caveolin-1, caveolin-2, vimentin, calponin2, tropomyosin, gelsolin, prolyl 4-hydroxylase alpha, EF-I-delta, or M2-isoform of pyruvate kinase in stromal cells adjacent to the neoplasm.