Inventors:
Richard E. Moore - Honolulu HI
Eiichi Furusawa - Honolulu HI
Ted R. Norton - Honolulu HI
Gregory M. L. Patterson - Honolulu HI
Jon S. Mynderse - Indianapolis IN
Assignee:
University of Hawaii - Honolulu HI
International Classification:
C12N 112, C12R 189, C12P 1708
Abstract:
Scytophycins A, B, C, D and E, an aldehyde and alcohol derivative of scytophycin B and the specified alkanoyl and benzoyl esters of scytophycins A, B, C, D and E and the B derivatives (scytophycin compounds) are novel antineoplastic and antifungal agents. Antifungal compositions containing a scytophycin compound and methods of inhibiting fungi, especially plant pathogenic fungi, using these compositions are included. A method for producing the scytophycin complex, comprising scytophycins A, B, C, D and E, using a new strain of the blue-green alga Scytonema pseudohofmanni, and a biologically purified culture of the alga are also provided.