Inventors:
Catherine Anne McCarty - Marshfield WI, US
James K. Burmester - Marshfield WI, US
Bickol N. Mukesh - Mansfield TX, US
Richard B. Patchett - Marshfield WI, US
Russell Alan Wilke - Brookfield WI, US
Assignee:
Marshfield Clinic - Marshfield WI
International Classification:
A61K 31/5377, C12Q 1/68, A61K 31/4704, A61P 27/06, A61K 31/138, A61K 31/222
US Classification:
5142362, 514652, 514546, 514312, 435 611
Abstract:
The invention provides a single nucleotide polymorphism (SNP) rs1042714 in the human ADRB2 gene (Gln27Glu) associated with a clinically meaningful reduction in intraocular pressure (IOP) in a human following treatment with a topical beta-blocker. Nucleic acids comprising the SNP are used to screen glaucoma-afflicted individuals to thereby provide an improved method for genotype-based prescribing of beta-blockers in glaucoma management.