Inventors:
Robyn Karlstadt - Cherry Hill NJ, US
Richard Lynn - Bala Cynwyd PA, US
Michael Burton - Lansdale PA, US
Mervyn Danilewitz - Villanova PA, US
International Classification:
A61K031/36, A61K031/277, A61K031/137
US Classification:
514/464000, 514/524000, 514/649000
Abstract:
This invention provides a method of treating functional gastrointestinal and genitourinary disorders in a mammal by administering to the mammal an effective amount of a hydroxycycloalkane phenethylamine of the following structural formula:
in which A is a moiety of the formula
where the dotted line represents optional unsaturation; Ris hydrogen or alkyl; Ris alkyl; Ris hydrogen, alkyl, formyl, or alkanol; Rand Rare, independently, hydrogen, hydroxyl, alkyl, alkoxy, alkanoyloxy, cyano, nitro, alkylmercapto, amino, alkylamino, dialkylamino, alkanamido, halo, trifluoromethyl, or taken together, methylene dioxy; Ris hydrogen or alkyl; and n is 0, 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof.