RICHARD ARTHUR STEINMAN
Medical Practice in Pittsburgh, PA
License number
Pennsylvania MD044190E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Pittsburgh, PA 15208
Personal information
See more information about RICHARD ARTHUR STEINMAN at radaris.comName
Address
Phone
7150 Reynolds St, Pittsburgh, PA 15208
505 Dogwood Cir, Havertown, PA 19083
1238 Callowhill St, Philadelphia, PA 19123
1502 Darby Rd, Havertown, PA 19083
7 Decatur Rd, Havertown, PA 19083
Professional information
Dr. Richard A Steinman, Pittsburgh PA - MD (Doctor of Medicine)
Specialties:
Internal Medicine
Address:
7150 Reynolds St, Pittsburgh 15208
Certifications:
Internal Medicine, 1990
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
Perelman School of Medicine University of Pennsylvania
Graduated: 1987
Upmc-Presbyterian
Pittsburgh Canc Inst
Perelman School of Medicine University of Pennsylvania
Graduated: 1987
Upmc-Presbyterian
Pittsburgh Canc Inst
Small Interfering Rna Libraries And Methods Of Synthesis And Use
US Patent:
7524653, Apr 28, 2009
Filed:
May 10, 2004
Appl. No.:
10/842353
Inventors:
Mark Nichols - Pittsburgh PA, US
Richard Steinman - Pittsburgh PA, US
Richard Steinman - Pittsburgh PA, US
Assignee:
University of Pittsburgh - of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
C12N 15/64, C12N 15/00, C07H 21/04
US Classification:
435 9141, 536 245, 435 9142, 4353201
Abstract:
In one aspect, the invention provides a random or semirandom siRNA (encoding) library. Another aspect of the invention pertains to methods for construction of random or semirandom siRNA (encoding) libraries. Another aspect of the invention is vector systems for use in constructing siRNA libraries and/or that can express single siRNAs and siRNA libraries both constitutively and in an inducible fashion. In another aspect, the invention provides a method of using an siRNA library. The siRNA library is introduced into a population of cells. The population of cells then is subjected to a selection process to select a subpopulation of cells exhibiting a different behavioral, biochemical, chemical, functional, molecular, morphological, phenotypic, or physical property from the remainder of population. Following the selection process, the subpopulation of cells can be isolated, analyzed, and/or cloned as desired. Such analysis of the subpopulation can be identification and sequencing of the siRNA species responsible for the different properties of the subpopulation relative to the remainder of the population.
Nucleosome-Based Biosensor
US Patent:
2009006, Mar 5, 2009
Filed:
Mar 19, 2007
Appl. No.:
11/687859
Inventors:
Richard Arthur Steinman - Pittsburgh PA, US
Sanford H. Leuba - Pittsburgh PA, US
Sanford H. Leuba - Pittsburgh PA, US
International Classification:
C40B 30/00, C12Q 1/68, C40B 40/06, C40B 50/08
US Classification:
506 7, 435 6, 506 16, 506 27
Abstract:
A nucleosome-based biosensor can detect events of transcriptional activity. The biosensor includes a nucleosome-forming DNA that contains at least one nuclear responsive DNA sequence; a core histone octamer and at least two labels. In one version, the two labels are placed on the DNA. In another version, one of the labels is attached to the DNA, while the other to the core histone octamer. The sensor function is effected by measuring an emission signal, associated with the labels, which is sensitive to whether the nucleosome-forming DNA is or is not in nucleosomal configuration. The biosensor finds application, for example, in high-throughput screening for ligands to known and orphan nuclear receptors, respectively.