Inventors:
Rando Allikmets - Frederick MD, US
Kent L. Anderson - Houston TX, US
Michael Dean - Frederick MD, US
Mark Leppert - Salt Lake City UT, US
Richard A. Lewis - Houston TX, US
Yixin Li - Houston TX, US
James R. Lupski - Houston TX, US
Jeremy Nathans - Baltimore MD, US
Amir Rattner - Baltimore MD, US
Noah F. Shroyer - Houston TX, US
Nanda Singh - Salt Lake City UT, US
Philip Smallwood - Woodbine MD, US
Hui Sun - Baltimore MD, US
Assignee:
Baylor College of Medicine - Houston TX
John Hopkins University - Baltimore MD
The United States of America as represented by the Secretary, Department of Health and Human Services - Washington DC
University of Utah Research Foundation - Salt Lake City UT
International Classification:
A61K 48/00, A61K 38/43, C07H 21/02
US Classification:
514 44R, 536 231, 424 941
Abstract:
The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.