Inventors:
Richard J. Johnson - Centennial CO, US
Miguel A. Lanaspa - Denver CO, US
Takuji Ishimoto - Greenwood Village CO, US
Assignee:
The Regents of the University of Colorado, a body - Denver CO
International Classification:
A61K 39/395, A61K 38/00, A61K 31/7052
US Classification:
4241581, 514 44 R, 514 11, 514 44 A
Abstract:
The invention relates to the use of isoform-specific fructokinase (ketohexokinase) (KHK) inhibitors alone or in combination with various agents to both prevent and treat a wide variety of diseases including, but not limited to, sugar craving, obesity, features of metabolic syndrome (including insulin resistance, hypertriglyceridemia, hypertension, and fatty liver), polyuria, proximal tubular injury, and diabetic kidney disease.