Richard A. Eiferman
Medical Practice at Dutchmans Pkwy, Louisville, KY

6448378, Sep 10, 2002

Dec 12, 2000

09/735182

Dale P. DeVore - Chelmsford MA 01824
Richard A. Eiferman - Louisville KY 40207
Edwin U. Keates - Villanova PA 19085

A61K 3817

530356, 530342, 530345, 530402, 514 2, 514 21, 514801, 514912, 514913

Disclosed herein are collagen films which rapidly dissolve at 35° C. Also disclosed are methods for the preparation of the collagen films and their use as a vehicle for delivering a dose of therapeutic compound to a specific tissue site.

5861486, Jan 19, 1999

Feb 16, 1996

8/602922

Dale P. Devore - Chelmsford MA
Richard A. Eiferman - Louisville KY

A61K 3817, A61K 3839

530356

A method of smoothing irregular corneal surfaces and removing protuberances from corneal surfaces by photoablative eximer laser keratectomy is provided. Collagen compositions for use in making collagen modulators useful in photoablative procedures are described. These compositions are applied to irregular corneal surfaces in sufficient amounts to at least fill in depressions or other irregularities on a corneal surface and are converted into a modulator, as a gel or polymerized film, prior to photoablation. The collagen modulators facilitate the photoablative smoothing of irregular corneal surfaces and protect adjacent corneal tissue from undesired photoablation.

6204365, Mar 20, 2001

Jan 18, 1999

9/232529

Dale P. Devore - Chelmsford MA
Richard A. Eiferman - Louisville KY

Collagenesis, Inc. - Beverly MA

A61K 3817, A61B 1700

530356

A method of smoothing irregular corneal surfaces and removing protuberances from corneal surfaces by photoablative eximer laser keratectomy is provided. Collagen compositions for use in making collagen modulators useful in photoablative procedures are described. These compositions are applied to irregular corneal surfaces in sufficient amounts to at least fill in depressions or other irregularities on a corneal surface and are converted into a modulator, as a gel or polymerized film, prior to photoablation. The collagen modulators facilitate the photoablative smoothing of irregular corneal surfaces and protect adjacent corneal tissue from undesired photoablation.

4959353, Sep 25, 1990

Apr 23, 1987

7/041695

Gregory L. Brown - Atlanta GA
Richard Eiferman - Louisville KY
Gregory L. Schultz - Louisville KY

University of Louisville Foundation - Louisville KY
Chiron Corporation - Emeryville CA

A61K 3736, C12P 2102

514 12

A method for treating corneal stromal wounds to promote regeneration of the affected tissue is provided. This method employs recombinant human epidermal growth factor.

6197934, Mar 6, 2001

May 22, 1998

9/083899

Dale P. DeVore - Chelmsford MA
Richard A. Eiferman - Louisville KY
Edwin U. Keates - Villanova PA

Collagenesis, Inc. - Beverly MA

A61K 3817, A61K 3800, C07K 100, A61M 100

530356

Disclosed herein are collagen films which rapidly dissolve at 35. degree. C. Also disclosed are methods for the preparation of the collagen films and their use as a vehicle for delivering a dose of therapeutic compound to a specific tissue site.

5492135, Feb 20, 1996

Sep 9, 1992

7/942657

Dale P. DeVore - Chelmsford MA
Richard A. Eiferman - Louisville KY

A61B 1700

128898

A method of smoothing irregular corneal surfaces and removing protuberances from corneal surfaces by photoablative excimer laser keratectomy is provided. Collagen compositions for use in making collagen modulators useful in photoablative procedures are described. These compositions are applied to irregular corneal surfaces in sufficient amounts to at least fill in depressions or other irregularities on a corneal surface and are converted into a modulator, as a gel or polymerized film, prior to photoablation. The collagen modulators facilitate the photoablative smoothing of irregular corneal surfaces and protect adjacent corneal tissue from undesired photoablation.