RENATO VINCENZO IOZZO
Medical Practice in Gladwyne, PA
License number
Pennsylvania MD027847E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Gladwyne, PA 19035
Personal information
See more information about RENATO VINCENZO IOZZO at radaris.comName
Address
Phone
1334 Beaumont Dr, Gladwyne, PA 19035
1334 Beaumont Dr, Gladwyne, PA 19035
Professional information
Method Of Suppressing Tumor Cell Growth By Administering A Decorin Gene Or Gene Product
US Patent:
6524573, Feb 25, 2003
Filed:
Sep 22, 2000
Appl. No.:
09/668084
Inventors:
Renato V. Iozzo - Gladwyne PA
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
A01N 6300
US Classification:
424 932, 424 9321, 4353201, 435325, 435455, 514 44
Abstract:
A method of suppressing tumor growth is provided wherein decorin gene or its gene products are administered so that epidermal growth factor receptor activity is induced. This specific mechanism has been linked to tumor growth suppression.
Endorepellin: Methods And Compositions For Inhibiting Angiogenesis
US Patent:
6821947, Nov 23, 2004
Filed:
Dec 4, 2001
Appl. No.:
10/006011
Inventors:
Renato V. Iozzo - Gladwyne PA
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
A01N 3718
US Classification:
514 2, 530350
Abstract:
Angiogenesis is a highly regulated process, yet many diseases are driven by unregulated angiogenesis. For example, the growth and metastasis of tumors is dependent on the growth of new blood vessels, which nurture the tumor by providing not only a growth-conducive environment but also a route by which metastatic cells can escape. The present invention provides an angiogenesis inhibiting agent endorepellin, its fragments or derivatives, or analogs thereof, which inhibit angiogenesis. The invention disclosed herein provides a novel therapeutic approach to the treatment of tumors, and other angiogenesis-mediated diseases or conditions, by inhibiting the generation of new blood vessels. The present invention also provides anti-endorepellin, its fragments or derivatives, or analogs thereof, antibodies for the detection, diagnosis and monitoring of angiogenesis-mediated diseases or conditions.