Inventors:
Carl White - Denver CO, US
Greg Del Val - Saint-Aubin/NE, CH
Rees Lee - Centennial CO, US
Assignee:
National Jewish Medical and Research Center - Denver CO
The United States Government as Represented by the Secretary of the Navy - Silver Spring MD
International Classification:
A61K038/06, A61K031/385, A61L009/04, A61K009/14
US Classification:
424046000, 514018000, 514440000
Abstract:
Disclosed are compositions and methods for decreasing the viscosity and/or cohesiveness of and/or increasing the liquefaction of excessively or abnormally viscous or cohesive mucus or sputum. Also disclosed are compositions and methods for inhibiting elastase in a patient. The compositions contains a compound containing a dithiol active-site in reduced state and optionally further contains a reducing system.