Inventors:
Raymond Kelleher - Boston MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
A61K 38/17, A61K 31/7088, C12Q 1/68, A61K 49/00, C12Q 1/48, A61P 25/28
US Classification:
424 92, 514 12, 514 44 A, 435 6, 435 15
Abstract:
The present invention provides compositions and methods for modulating, e.g., enhancing, cognitive function. The methods involve modulation of translation, modulation of a MAPK signaling pathway, or both. The invention further provides screening methods useful in identifying compounds that modulate, e.g, enhance, cognitive function. The invention further provides method of treating a subject to modulate cognitive function.