Inventors:
Zhonghua Zhang - Nashville TN, US
Raymond DuBois - Nashville TN, US
International Classification:
A61K031/60, A61K031/415, C12Q001/68, A61K031/192
US Classification:
514/165000, 435/006000, 514/406000, 514/570000
Abstract:
The invention is based on evidence that the anti-neoplastic effects of high dose NSAID treatments involve a complex pathway which involves alterations in the expression of genes which regulate a number of biological processes. The invention allows a more accurate molecular picture of cancer response to NSAIDS, and in so doing, allows one to assess the efficacy of a particular NSAID on a particular cancer, and to screen NSAIDS, and drugs generally, for their ability to produce NSAID-like anti-neoplastic effects.