Inventors:
Raymond C. Bergan - Chicago IL, US
Karl A. Scheidt - Evanston IL, US
Assignee:
NORTHWESTERN UNIVERSITY - Evanston IL
International Classification:
A61K 31/352, A61K 31/7105, C12N 5/09, C12N 9/99, A61P 35/04, C07D 311/36, G01N 33/573, C12Q 1/68, G01N 21/00, A61K 31/7088, C12Q 1/48
US Classification:
514 44 A, 514456, 435375, 435184, 435 15, 549403, 435 74, 435 613, 435 612, 435 61
Abstract:
The present invention provides compounds and methods of inhibiting and treating metastatic prostate cancer. The compounds include MEK4 inhibitors. In another aspect the invention provides methods of identifying inhibitors of metastatic prostate cancer by screening for inhibitors of MEK4.