Inventors:
Catriona Helen M. Jamieson - La Jolla CA, US
Irving L. Weissman - Stanford CA, US
Siddhartha Jaiswal - San Francisco CA, US
Ravindra Majeti - Stanford CA, US
International Classification:
A61K 39/395, C12N 5/08
Abstract:
Methods are provided to manipulate phagocytosis of cells, including hematopoietic cells, e.g. circulating hematopoietic cells, bone marrow cells, etc.; and solid tumor cells. In some embodiments of the invention the circulating cells are hematopoietic stem cells, or hematopoietic progenitor cells, particularly in a transplantation context, where protection from phagocytosis is desirable. In other embodiments the circulating cells are leukemia cells, particularly acute myeloid leukemia (AML), where increased phagocytosis is desirable.