Inventors:
Yun-Long Li - Wilmington DE, US
Jincong Zhuo - Boothwyn PA, US
David Burns - Philadelphia PA, US
Wenqing Yao - Kennett Square PA, US
Ravi Kumar Jalluri - Avondale PA, US
International Classification:
A61K 31/397, C07D 405/14, A61K 31/4545, A61K 31/496, C07D 401/14, C07D 401/06, A61K 31/454, C07D 413/14, A61K 31/5377, A61K 31/55, A61K 31/4709, A61P 19/02, A61P 35/00, A61P 9/00, A61P 17/00, A61P 37/08
US Classification:
51421018, 546187, 514316, 544364, 51425311, 546193, 514318, 546208, 514326, 544130, 5142308, 5142372, 540598, 51421705, 546153, 514312
Abstract:
The present invention provides compounds of the formula:its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof, solvates thereof, metabolites thereof, and pharmaceutically acceptable salts, wherein the ring A substituent groups are fully defined in the following disclosure. The compounds of formula are inhibitors of metalloproteases such as matrix metalloproteases and sheddases, and are useful in treating diseases such as rheumatoid arthritis, psoriasis, neoplastic diseases, allergies and all those diseases wherein inhibition of MMPs is desirable.