RAVI K AMARAVADI
Medical Practice in Delaware
License number
Pennsylvania MD422849
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Delaware
Media, PA 19063
Media, PA 19063
Professional information
Novel Bisaminoquinoline Compounds, Pharmaceutical Compositions Prepared Therefrom And Their Use
US Patent:
2014005, Feb 20, 2014
Filed:
Apr 26, 2012
Appl. No.:
14/114049
Inventors:
Ravi K. Amaravadi - Media PA, US
Jeffrey Winkler - Wynnewood PA, US
Jeffrey Winkler - Wynnewood PA, US
International Classification:
A61K 31/4709, C07D 401/14, A61K 45/06, C07D 401/12
US Classification:
424 852, 546163, 514313
Abstract:
The present invention relates to novel bisaminoquinoline compounds, pharmaceutical compositions comprising these novel compounds and methods for inhibiting autophagy in biological systems. Methods of treating cancer in patients in need using compounds and/or compositions according to the present invention alone or in combination with at least one additional anticancer agent represent additional aspects of the invention. Methods of treating disease states and/or conditions in which inhibition of autophagy plays a favorable treatment role including rheumatoid arthritis, malaria, antiphospholipid antibody syndrome, lupus, chronic urticaria and Sjogren's disease, with compounds according to the present invention represent additional aspects of the invention.
Combination Antineoplastic Therapy
US Patent:
2012012, May 24, 2012
Filed:
May 4, 2010
Appl. No.:
13/319604
Inventors:
Ravi Kumar Amaravadi - Media PA, US
Craig B. Thompson - Merion PA, US
Craig B. Thompson - Merion PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A61K 31/4706, A61P 35/00, A61K 31/4709, A61K 31/49, A61K 31/47, A61K 31/675
US Classification:
514 80, 514291
Abstract:
The present invention is directed to methods of using a sirolimus drug and chloroquine or a quinoline derivative in combination. Methods of use are also described.