DR. RAVI CHARI, MD
Radiology in Nashville, TN

2005011, Jun 2, 2005

Sep 30, 2004

10/955331

Wei-Chiang Lin - Miami FL, US
Steven Toms - Shaker Heights OH, US
Ravi Chari - Nashville TN, US

Vanderbilt University - Nashville TN

A61B005/00

600407000, 600476000

A method for detecting death process of a cell or tissue of a living subject. In one embodiment, the method includes the steps of illuminating the cell or tissue of the living subject with a coherent light, collecting fluorescent light returned from the illuminated cell or tissue of the living subject, identifying a NAD(P)H peak of a spectrum of the collected fluorescent light with a wavelength, λ, and obtaining the intensity of the NAD(P)H peak of the spectrum of the collected fluorescent light substantially corresponding to the wavelength λ. These steps are repeated at sequential stages until the intensity of the NAD(P)H peak of the spectrum at a current stage is less than the intensity of the NAD(P)H peak of the spectrum at an earlier stage immediately prior to the current stage so as to detect death process of the cell of the living subject at the current stage using the intensity of the NAD(P)H peak of the spectrum.

7979107, Jul 12, 2011

Aug 6, 2009

12/537008

Wei-Chiang Lin - Miami FL, US
Steven A. Toms - Shaker Heights OH, US
Ravi S. Chari - Nashville TN, US

Vanderbilt University - Nashville TN
Cleveland Clinic Foundation - Cleveland OH

A61B 5/05

600407, 600473, 600476, 356 73, 356318

A method for differentiating malignant in vivo liver tissues from normal in vivo liver tissues of a living subject includes the steps of: (a) illuminating a first area and a second area of in vivo liver tissues of the living subject with a first excitation light, (b) measuring an intensity of fluorescent light emitted from each of the first area and the second area of in vivo liver tissues in response to the first excitation light as a function of wavelength so as to obtain a first and a second fluorescent spectra, respectively, (c) illuminating the first area and the second area of in vivo liver tissues with a second excitation light, (d) measuring an intensity of diffuse light reflected by each of the first area and the second area of in vivo liver tissues in response to the second excitation light as a function of wavelength so as to obtain a first and a second diffused reflectance spectra, respectively, and (e) identifying one of the first area and the second area of in vivo liver tissues as malignant liver tissues and the other one of the first area and the second area of in vivo liver tissues as normal liver tissues, by comparing the first fluorescence spectrum and the second florescence spectrum, and comparing the first diffused reflection spectrum and the second diffused reflection spectrum.

2011029, Dec 1, 2011

May 26, 2011

13/116994

Wei-Chiang Lin - Miami FL, US
Steven A. Toms - Shaker Heights OH, US
Ravi S. Chari - Nashville TN, US

VANDERBILT UNIVERSITY - Nashville TN

A61B 6/00, A61B 18/04

600476, 606 33

A method for detecting death process of a cell or tissue of a living subject. In one embodiment, the method includes the steps of illuminating the cell or tissue of the living subject with a coherent light, collecting fluorescent light returned from the illuminated cell or tissue of the living subject, identifying a NAD(P)H peak of a spectrum of the collected fluorescent light with a wavelength, λ, and obtaining the intensity of the NAD(P)H peak of the spectrum of the collected fluorescent light substantially corresponding to the wavelength λ. These steps are repeated at sequential stages until the intensity of the NAD(P)H peak of the spectrum at a current stage is less than the intensity of the NAD(P)H peak of the spectrum at an earlier stage immediately prior to the current stage so as to detect death process of the cell of the living subject at the current stage using the intensity of the NAD(P)H peak of the spectrum.

2008008, Apr 17, 2008

Aug 18, 2007

11/840949

Clayton Knox - Philadelphia PA, US
Ravi Chari - Nashville TN, US
Ian Nicoud - Seattle WA, US
C. Pinson - Nashville TN, US

A61K 33/24, A01N 1/02, A61P 9/00, A61P 9/10, A61K 31/69

424617000, 435001100, 514064000

The present invention concerns the use of calcium influx inhibitors for treatment of organs and tissues to inhibit damage caused by ischemia/reperfusion events such as transplant, other surgeries, and trauma. It includes methods and apparatuses for achieving stasis in tissue, so as to preserve and/or protect them. In specific embodiments, preservation methods and apparatuses for preserving tissue for transplantation purposes is provided.