DR. RAPHAEL C LEE, MD, SCD
Radiology in Chicago, IL

5700688, Dec 23, 1997

Jun 7, 1995

8/488134

Raphael C. Lee - Chicago IL
David Huang - Cambridge MA

Massachusetts Institute of Technology - Cambridge MA

C12M 300, G01N 300, A61B 1756

4352871

The present invention pertains to a mechanical testing apparatus for determining the mechanical properties of an oriented tissue-equivalent, while simultaneously providing a suitable cell culture environment. The mechanical testing apparatus comprises an incubator equipped with means for controlling the atmosphere and means for controlling the temperature inside said incubator. Located within the incubator chamber are means for securing, in a desired location, the oriented tissue-equivalent to be mechanically tested. Further, the apparatus is equipped with means for controlling the length of the oriented tissue-equivalent, means for determining the force generated by the oriented tissue-equivalent, means for determining the length of the oriented tissue-equivalent and means for conditioning and recording force and length measurements.

7255627, Aug 14, 2007

Feb 1, 2005

11/049525

Elena N. Bodnar - Hinsdale IL, US
Raphael C. Lee - Chicago IL, US
Sandra Marijan - Chicago IL, US

Avocet Polymer Technologies, Inc. - Plainfield IL

A41D 13/00, A41C 3/12, A41C 3/00

450 1, 2 4, 2 9, 12820619

A garment device convertible to one or more facemasks wherein the garment device has a plurality of detachable cup sections. Each of the cup sections has a filter device, an inner portion positionable adjacent to the inner area of the user's chest, and an outer portion positionable adjacent to the outer area of the user's chest. The garment device has at least one securing device detachably coupling the inner portions of the cup sections to one another, and the garment device has at least one other securing device attached to the outer portion of at least one of the cup sections. This other securing device is operable to: (a) detachably couple the outer portions of the cup regions to one another; and (b) for each one of the cup sections, attach the outer portion of said cup region to the inner portion of said cup region after said cup region is detached from the other cup region, thereby converting the garment device to a plurality of facemasks.

5605687, Feb 25, 1997

Jun 5, 1995

8/461255

Raphael C. Lee - Chicago IL

Arch Development Corporation - Chicago IL

A61K 906, A61K 912, A61K 3177

424 7896

Novel methods for the treatment of tissue damage resulting from cell membrane permeabilization due to electrical injury are disclosed. Such methods include treatment with a surface active copolymer which is herein shown to promote membrane repair. The administration of Poloxamer 188 is shown to reduce tissue inflammation and damage following electrical injury in vivo. Also disclosed are methods for the treatment of cell and tissue damage after electrical injury using a surface active copolymer in combination with a high energy phosphate compound capable of recharging cellular energy stores and potentiating cell repair and survival. Compositions comprising surface active copolymers for intravenous, intramuscular, and topical use are also disclosed, along with novel compositions comprising a combination of a surface active copolymer and a high energy phosphate compound.

2003011, Jun 26, 2003

Apr 24, 2002

10/132542

Riyi Shi - West Lafayette IN, US
Richard Borgens - Delphi IN, US
Raphael Lee - Chicago IL, US

A61K031/765

424/078370

To achieve, an in vivo repair of injured mammalian nerve tissue, an effective amount of a biomembrane fusion agent is administered to the injured nerve tissue. The application of the biomembrane fusion agent may be preformed by directly contacting the agent with the nerve tissue at the site of the injury. Alternatively, the biomembrane fusion agent is delivered to the site of the injury through the blood supply after administration of the biomembrane fusion agent to the patient. The administration is preferably by parenteral administration including including intravascular, intramuscular, subcutaneous, or intraperitoneal injection of an effective quantity of the biomembrane fusion agent so that an effective amount is delivered to the site of the nerve tissue injury.

5470568, Nov 28, 1995

Feb 13, 1992

7/835271

Raphael C. Lee - Chicago IL

Arch Development Corporation - Chicago IL

A61K 906, A61K 912, A61K 3177

424 7802

Novel methods for prophylaxis and treatment of tissue damage resulting from cell membrane permeabilization are disclosed. Compositions comprising a surface active copolymer are employed to prevent permeabilization or to promote membrane repair. Methods for enhancement of cell survival following membrane permeabilization in vitro are also disclosed, along with methods for increasing the efficacy of transfection of cells with foreign exogenous macromolecules, in particular DNA, also involving treatment of permeabilized cells with a surface active copolymer. Also disclosed are novel methods for prophylaxis and treatment of tissue damage, and for enhancement of cell survival and transfection efficacy, using a surface active copolymer in combination with high energy phosphate compounds which are capable of recharging cellular energy stores and thereby potentiating cell repair and survival. Compositions comprising surface active copolymers for intravenous, intramuscular, and topical use are also disclosed, along with novel compositions comprising a combination of a surface active copolymer and a high energy phosphate compound.

5132119, Jul 21, 1992

Dec 17, 1990

7/629080

Raphael C. Lee - Chicago IL

Massachusetts Institute of Technology - Cambridge MA

A61K 31275, A61K 3144, A61K 3324

424646

This invention pertains to a method for controlling hypertrophic wound healing disorders by administering calcium channel blockers to the wound site. Calcium channel blockers are found to regulate fibroblast biosynthesis and can therefore be used to therapeutically control diseases characterized by excessive fibroblast biosynthesis.

5902609, May 11, 1999

Oct 25, 1996

8/740242

Raphael C. Lee - Chicago IL

Massachusetts Institute of Technology - Cambridge MA

A61K33/26;31/58;31/55;31/54

424646

This invention pertains to a composition for controlling wound scar production containing a calcium antagonist and a protein synthesis inhibitor. The method can be used to minimize wound scars, such as hypertrophic wound healing disorders keloids and burn scar contractures in humans or other mammals, particularly those individually prone to excesssive scarring Calcium antagonist treatment can also be used to control diseases associated with excessive scarring. such as cirrhosis of the liver, constructive pericarditis Dupuytren's disease of the hand, plantar fibrosis of the foot, and various other fibromatoses.