Inventors:
Hani A. Awad - Rochester NY, US
Edward M. Schwarz - Rochester NY, US
Susan Bukata - Pittsford NY, US
J. Edward Puzas - Pittsford NY, US
Regis J. O'Keefe - Rochester NY, US
Randy Rosier - Rochester NY, US
Assignee:
UNIVERSITY OF ROCHESTER - Rochester NY
International Classification:
A61K 38/29, A61P 19/00
Abstract:
Methods of improving an outcome of a bone allograft procedure in a subject suffering from a massive bone defect are described, including providing a bone allograft to the subject and intermittently providing said subject with parathyroid hormone (PTH); where the PTH is provided in an amount effective to enhance in or adjacent to a bone allograft, relative to a patient not provided the PTH, at least one of callus bone volume, callus mineral content, callus bridging, graft stiffness, graft incorporation, and graft resistance to an applied torque.