DR. RANDALL C DUNN, M.D.
Medical Practice at Fannin St, Houston, TX

6461640, Oct 8, 2002

Nov 12, 1997

08/967619

Jeffrey A. Hubbell - San Marino CA
Jennifer L. Hill-West - Pasadena CA
Randall C. Dunn - Houston TX

Board of Regents, The University of Texas System - Austin TX

A61K 910

424484, 424486, 514822, 514944

A method of preventing adhesions by topical administration of fibrinolysis enhancing agents is described. The method uses a topically applied polymeric matrix for delivery of a fibrinolytic agent, preferably urokinase, tPA, hirudin, or most preferably, ancrod. In the most preferred embodiment, the matrix is extremely thin and is polymerized in situ to form a biodegradable polymeric matrix. The matrix provides controlled release of the agent over a period of time effective to prevent surgical adhesions and is biodegradable, usually within the same time frame. Examples demonstrate that the combination of the matrix and the urokinase, tPA, hirudin, or ancrod is effective in preventing surgical adhesions.

5468505, Nov 21, 1995

Dec 10, 1993

8/165392

Jeffrey A. Hubbell - Austin TX
Jennifer L. Hill-West - Austin TX
Randall C. Dunn - Houston TX

Board of Regents, The University of Texas System - Austin TX

C08G 6308, C08G 6700, A61K 958

424484

A method of preventing adhesions by topical administration of fibrinolysis enhancing agents is described. The method uses a topically applied polymeric matrix for delivery of a fibrinolyic agent, preferably urokinase, or tPA. In the most preferred embodiment, the matrix is extremely thin and is polymerized in situ to form a biodegradable polymeric matrix. The matrix provides controlled release of the agent over a period of time effective to prevent surgical adhesions and is biodegradable, usually within the same time frame. Examples demonstrate that the combination of the matrix and the urokinase or tPA is effective in preventing surgical adhesions.