Inventors:
Jaroslaw P. Maciejewski - Cleveland OH, US
Hideki Makishima - South Euclid OH, US
Ramon Tiu - Cleveland OH, US
Valeria Visconte - Cleveland OH, US
International Classification:
C12Q 1/68
Abstract:
One aspect of the present disclosure includes a method for predicting the prognosis of a subject with a myeloid malignancy. One step of the method includes obtaining a biological sample from the subject. Next, at least one mutation in a spliceosome-associated protein, or a polynucleotide encoding the spliceosome-associated protein that results in defective splicing can be detected in the biological sample. The presence of at least one mutation in the spliceosome-associated protein, or a polynucleotide encoding the spliceosome-associated protein, is indicative of the subject's prognosis.