Inventors:
Peter S. Lu - Palo Alto CA, US
Chamorro Somoza Diaz-Sarmiento - Mountain View CA, US
Brian Seed - Boston MA, US
Ramnik Xavier - Boston MA, US
Bryan Allen Irving - San Francisco CA, US
Assignee:
Arbor Vita Corporation - Fremont CA
The General Hospital Corporation - Boston MA
International Classification:
A61K 39/00, G01N 33/53, C12N 5/07, A61P 37/00, A61P 3/10, A61P 19/02, A61P 17/06, A61P 35/02, A61P 35/00, A61P 1/00, C07K 2/00, C07K 14/00
US Classification:
4241851, 435 71, 435375, 4241841, 4241921, 530300, 530324
Abstract:
Methods for modulating immune cell signaling are provided. In general such methods involve modulating an interaction between a PDZ protein and a PDZ ligand protein whose interaction affects the composition and/or distribution of lipid rafts in an immune cell. Modulators that enhance or inhibit such interactions are also disclosed, as well as methods of screening for such modulators.