Inventors:
M. Robert Leanna - Grayslake IL
Steven M. Hannick - Highland Park IL
Michael Rasmussen - Kenosha WI
Lakshmi Bhagavatula - Vernon Hills IL
Pulla Reddy Singam - Des Plaines IL
Bradley D. Gates - Mount Prospect IL
Lawrence Kolaczkowski - Gurnee IL
Ramesh R. Patel - Chicago IL
Greg Wayne - Vernon Hills IL
Greg Lannoye - Wildwood IL
Weijiang Zhang - Grayslake IL
Zhenping Tian - Grayslake IL
Kirill A. Lukin - Mundelein IL
Bikshandarkoil A. Narayanan - Mundelein IL
David A. Riley - Kenosha WI
Howard Morton - Gurnee IL
Cynthia B. Curty - Gurnee IL
Daniel Plata - Wadsworth IL
John Bellettini - Waukegan IL
Bhadra Shelat - Lake Forest IL
Tiffany Spitz - Highland Park IL
International Classification:
C07D47318, C07D47340, C07D31730, C07F 718, C12P 1718
Abstract:
Methods and novel intermediates of the formula: ##STR1##
wherein R. sub. 6 and R. sub. 7 are lower alkyl or benzyl or R. sub. 6 and R. sub. 7 taken together are --CH. sub. 2 CH. sub. 2 --, --CH. sub. 2 CH. sub. 2 CH. sub. 2 -- or --CH. sub. 2 CH. sub. 2 CH. sub. 2 CH. sub. 2 CH. sub. 2 --, R. sub. 8 is C. sub. 1 -C. sub. 21 alkyl or a C. sub. 2 -C. sub. 21 monounsaturated alkenyl, which may optionally be substituted with substitution substituents independently selected from the group consisting of hydroxy, C. sub. 1 -C. sub. 6 alkyl, C. sub. 1 -C. sub. 6 alkoxy, C. sub. 1 -C. sub. 6 alkoxy C. sub. 1 -C. sub. 6 alkyl, C. sub. 1 -C. sub. 6 alkanoyl, amino, halo, cyano, azido, oxo, mercapto and nitro, and R. sub. 9 is an alcohol protecting group. The intermediates are useful for the preparation of acyclic nucleoside derivatives of the formula: ##STR2##
where one of R. sub. 1 and R. sub.