DR. RALPH WEISSLEDER, MD PHD
Radiology at Fruit St, Boston, MA
License number
Massachusetts 77481
Category
Radiology
Type
Diagnostic Radiology
Address
Address
55 Fruit St, Boston, MA 02114
Phone
(617) 726-8396
(617) 726-4891 (Fax)
(617) 726-8226
(617) 643-6133 (Fax)
(617) 726-4891 (Fax)
(617) 726-8226
(617) 643-6133 (Fax)
Personal information
See more information about RALPH WEISSLEDER at radaris.comName
Address
Phone
197 8Th St APT 731, Charlestown, MA 02129
11 Nichols St, Peabody, MA 01960
197 8Th St, Charlestown, MA 02129
Organization information
See more information about RALPH WEISSLEDER at bizstanding.comRalph Weissleder MD,PHD
32 Fruit St, Boston, MA 02114
Industry:
Radiology
Phone:
(617) 726-8226 (Phone)
Ralph Weissleder
Ralph Weissleder MD
185 Cambridge St, Boston, MA 02114
Categories:
Radiology Physicians & Surgeons
Phone:
(617) 726-2000 (Phone)
Cardiac Unit Associate - Ralph Weissleder MD
32 Fruit St #5B, Boston, MA 02114
Categories:
Radiology Physicians & Surgeons
Phone:
(617) 724-6750 (Phone)
Professional information
Use Of An Internalizing Transferrin Receptor To Image Transgene Expression
US Patent:
6511967, Jan 28, 2003
Filed:
Apr 21, 2000
Appl. No.:
09/552993
Inventors:
Ralph Weissleder - Charlestown MA
James P. Basilion - Brookline MA
Ennio Antonio Chiocca - Wakefield MA
James P. Basilion - Brookline MA
Ennio Antonio Chiocca - Wakefield MA
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61K 3170
US Classification:
514 44, 435 6, 536 231, 536 234
Abstract:
Cells can be imaged, e. g. , in vivo, in an animal or human subject by introducing into the cells a nucleic acid encoding an internalizing receptor, administering to the animal or human subject a reporter complex including one or more receptor-specific reporter moieties linked to one or more reporter groups, such as magnetic particles, and detecting the reporter complex, e. g. , using magnetic resonance imaging, and thus detecting the cells. If a specific gene is expressed in a constant, known ratio compared to expression of the receptor, the expression of that gene can be monitored by detecting the reporter complex, and thus, concomitantly, expression of the internalizing receptor and the specific gene.
Intramolecularly-Quenched Near Infrared Flourescent Probes
US Patent:
6592847, Jul 15, 2003
Filed:
Jun 27, 2000
Appl. No.:
09/604145
Inventors:
Ralph Weissleder - Charlestown MA
Ching-Hsuan Tung - Natick MA
Umar Mahmood - Boston MA
Lee Josephson - Arlington MA
Alexei Bogdanov - Arlington MA
Ching-Hsuan Tung - Natick MA
Umar Mahmood - Boston MA
Lee Josephson - Arlington MA
Alexei Bogdanov - Arlington MA
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61B 1000
US Classification:
424 96, 424 111, 424 91, 424 165
Abstract:
An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i. e. , activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.
Fluorescence-Mediated Molecular Tomography
US Patent:
7383076, Jun 3, 2008
Filed:
May 22, 2003
Appl. No.:
10/443463
Inventors:
Vasilis Ntziachristos - Somerville MA, US
Ralph Weissleder - Charlestown MA, US
Ralph Weissleder - Charlestown MA, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61B 6/00
US Classification:
600473, 600431, 600309, 600310
Abstract:
This invention relates to a fluorescence-mediated molecular tomographic imaging system, designed to detect near-infrared fluorescence activation in deep tissues. The system can use targeted fluorescent molecular probes or highly sensitive activatable fluorescence molecular probes. Such probes add molecular specificity and yield high fluorescence contrast, to allow early detection and molecular target assessment of diseased tissue, such as cancers, in vivo. The new tomographic imaging system enables three-dimensional localization in deep tissues and quantitation of molecular probes.
Compositions And Methods For Imaging Gene Expression
US Patent:
2002014, Oct 3, 2002
Filed:
Dec 18, 2000
Appl. No.:
09/739068
Inventors:
Alexei Bogdanov - Arlington MA, US
Ralph Weissleder - Charlestown MA, US
Maria Simonova - Boston MA, US
Ralph Weissleder - Charlestown MA, US
Maria Simonova - Boston MA, US
Assignee:
The General Hospital Corporation, a Massachusetts corporation
International Classification:
C12Q001/68, G01N033/53, C07K014/435
US Classification:
435/006000, 435/007100, 530/400000
Abstract:
Described are short peptide sequences, termed recombinant peptide chelates (RPCs), and the imaging marker genes that encode them. The RPCs can be expressed in parallel with the expression of any other desired gene (e.g., a therapeutic gene), and used to easily confirm the expression of the therapeutic gene product. The RPCs are expressed in the cell or on the cell surface concurrently with the therapeutic gene product, and can be assayed by standard imaging techniques.
Intramolecularly-Quenched Near Infrared Fluorescent Probes
US Patent:
2003021, Nov 27, 2003
Filed:
Feb 7, 2003
Appl. No.:
10/360890
Inventors:
Ralph Weissleder - Charlestown MA, US
Ching-Hsuan Tung - Natick MA, US
Umar Mahmood - Boston MA, US
Lee Josephson - Arlington MA, US
Alexei Bogdanov - Arlington MA, US
Ching-Hsuan Tung - Natick MA, US
Umar Mahmood - Boston MA, US
Lee Josephson - Arlington MA, US
Alexei Bogdanov - Arlington MA, US
Assignee:
The General Hospital Corporation, a Massachusetts corporation
International Classification:
A61K049/00, C07F005/00, C07H021/04, C07K014/00
US Classification:
424/009600, 530/400000, 536/023100, 536/018700, 534/015000
Abstract:
An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.
Hydrogel Compositions And Methods Of Use
US Patent:
5514379, May 7, 1996
Filed:
Aug 7, 1992
Appl. No.:
7/927068
Inventors:
Ralph Weissleder - Charlestown MA
Alexei Bogdanov - Newton MA
Alexei Bogdanov - Newton MA
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61K 910, A61K 4900, A61K 4904
US Classification:
424426
Abstract:
Biocompatible, biodegradable, hydrogels are prepared from a backbone bonded to a cross-linking agent. Suitable backbones include proteins and polysaccharides, e. g,, albumin, polymannuronic acid, or polygalacturonic acid. Suitable cross-linking agents include polyvalent derivatives of polyethylene or polyalkylene glycol. These hydrogel compositions may be loaded with diagnostic labels, e. g,, radiopaque, paramagnetic, or superparamagnetic materials, or therapeutic drugs, e. g. , chemotherapeutic drugs, antibiotics, or cells that produce therapeutic agents. This invention also relates to methods of use of such hydrogels for imaging during interventional procedures of a patient.
Graft Co-Polymer Adducts Of Platinum (Ii) Compounds
US Patent:
5871710, Feb 16, 1999
Filed:
Oct 28, 1996
Appl. No.:
8/738177
Inventors:
Alexei Bogdanov - Newton MA
Ralph Weissleder - Charlestown MA
Thomas J. Brady - Winchester MA
Ralph Weissleder - Charlestown MA
Thomas J. Brady - Winchester MA
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61K 5108, A61K 4900, A61K 3174, A61K 3714
US Classification:
424 165
Abstract:
A biocompatible graft co-polymer adduct including a polymeric carrier, a protective chain linked to the polymeric carrier, a reporter group linked to the carrier or to the carrier and the protective chain, and a reversibly linked Pt(II) compound. The invention also relates to a method of treating a disease in a patient, particularly cancer, by administering to the patient a therapeutically effective amount of the adduct, and may include scanning the patient using an imaging technique which can provide a visible image of the distribution of the adduct.
Blood Pool Imaging Composition And Method Of Its Use
US Patent:
5605672, Feb 25, 1997
Filed:
Jun 9, 1993
Appl. No.:
8/074319
Inventors:
Alexei A. Bogdanov - Newton MA
Ralph Weissleder - Charlestown MA
Thomas J. Brady - Winchester MA
Ronald Callahan - Boston MA
Ralph Weissleder - Charlestown MA
Thomas J. Brady - Winchester MA
Ronald Callahan - Boston MA
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61K 5100, C07F 500
US Classification:
424 165
Abstract:
The invention features a method of blood pool imaging which utilizes an imaging agent which can be easily labelled with a radioactive isotope and injected into a patient. The imaging agent is a covalent conjugate of a polymeric carrier, protective groups, and chelating groups. The imaging agent is preferably provided in the form of a blood pool imaging composition, which includes an imaging agent of the invention, a buffer and a reducing compound. A radioactive isotope is added to the blood pool imaging composition to label the imaging agent, and the composition containing the labelled imaging agent is injected intravenously into a patient.
Intramolecularly-Quenched Near Infrared Fluorescent Probes
US Patent:
8486373, Jul 16, 2013
Filed:
Nov 1, 2004
Appl. No.:
10/979755
Inventors:
Ralph Weissleder - Charlestown MA, US
Ching-Hsuan Tung - Natick MA, US
Umar Mahmood - Boston MA, US
Lee Josephson - Arlington MA, US
Alexei Bogdanov - Arlington MA, US
Ching-Hsuan Tung - Natick MA, US
Umar Mahmood - Boston MA, US
Lee Josephson - Arlington MA, US
Alexei Bogdanov - Arlington MA, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61B 10/00, A61B 5/00, A61B 8/00
US Classification:
424 96, 424 111, 424 165, 424 91
Abstract:
An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i. e. , activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.
Magneitc-Nanoparticle Conjugates And Methods Of Use
US Patent:
2003009, May 15, 2003
Filed:
Jun 6, 2002
Appl. No.:
10/165258
Inventors:
Lee Josephson - Arlington VA, US
Ralph Weissleder - Charlestown MA, US
J. Perez - Boston MA, US
Ralph Weissleder - Charlestown MA, US
J. Perez - Boston MA, US
International Classification:
C12Q001/68, G01N033/53, G01N033/553
US Classification:
435/006000, 435/007500, 436/526000
Abstract:
The present invention provides novel compositions of binding moiety-nanoparticle conjugates, aggregates of these conjugates, and novel methods of using these conjugates, and aggregates. The nanoparticles in these conjugates can be magnetic metal oxides, either monodisperse or polydisperse. Binding moieties can be, e.g., oligonucleotides, polypeptides, or polysaccharides. Oligonucleotide sequences are linked to either non-polymer surface functionalized metal oxides or with functionalized polymers associated with the metal oxides. The novel compositions can be used in assays for detecting target molecules, such as nucleic acids and proteins, in vitro or as magnetic resonance (MR) contrast agents to detect target molecules in living organisms.