DR. RALPH EDWARD HOLMES, M.D.
Medical Practice at Frost St, San Diego, CA

6531146, Mar 11, 2003

Mar 12, 2001

09/805411

Christopher J. Calhoun - San Diego CA
Ralph E. Holmes - San Diego CA

MacroPore, Inc. - San Diego CA

A61F 202

424426, 5147723

Resorbable polylactide polymer scar tissue reduction barrier membranes and methods of their application are disclosed. The scar-tissue reduction barrier membranes are constructed entirely of polylactide resorbable polymers, which are engineered to be absorbed into the body relatively slowly over time in order to reduce potential negative side effects. The scar tissue reduction barrier membranes are formed to have thicknesses on the order of microns, such as, for example, thicknesses between 10 and 300 microns. The membranes are preshaped with welding flanges and stored in sterile packaging.

2012020, Aug 16, 2012

Apr 24, 2012

13/454622

Steven R. Cohen - La Jolla CA, US
Ralph E. Holmes - San Diego CA, US
J. Peter Amis - Carlsbad CA, US
Horst R. Fichtner - Carlsbad CA, US

MEDTRONIC PS MEDICAL INC. - Minneapolis MN

A61B 17/80

606 71

A device for early stabilizing of distracted tissue that includes a first implant, a second implant, a sliding expansion mechanism and a stabilizer. The first implant is capable of being attached to a first tissue region. The second implant is capable of being attached to a second tissue region. The sliding expansion mechanism engages the first implant and the second implant for distracting the first implant away from the second implant to create a distraction space for formation of the distracted tissue. The stabilizer rigidly fixes the first implant and the second implant after disengagement of the sliding expansion mechanism to rigidly stabilize the distracted tissue. The stabilizer includes in whole or in part a biodegradable, bioerodible or bioresorbable material.

7744915, Jun 29, 2010

Jan 12, 2007

11/653064

Christopher J. Calhoun - San Diego CA, US
Ralph E. Holmes - San Diego CA, US
G. Bryan Cornwall - San Diego CA, US

MAST Biosurgery AG - Zurich

A61K 9/00, A61F 2/12

424426, 623 8

An anti-adhesion membrane is placed onto an implant introduced into a surgical site of a patient to prevent post-surgical adhesions between the implant and surrounding tissue. The implant may comprise either biological material, such as a transplanted organ, or non-biological material such as a medical device. The membrane may be applied in a variety of ways. In one example, a membrane according to the present invention is shrink-wrapped around a pace-maker. In another example, a breast implant is spray-coated or dipped with the membrane material.

7767222, Aug 3, 2010

Jul 31, 2003

10/632014

Christopher J. Calhoun - San Diego CA, US
Ralph E. Holmes - San Diego CA, US
G. Bryan Cornwall - San Diego CA, US

MAST Biosurgery AG - Zurich

A61K 9/00, A61F 2/12

424426, 623 8

An anti-adhesion membrane is placed onto an implant introduced into a surgical site of a patient to prevent post-surgical adhesions between the implant and surrounding tissue. The implant may comprise either biological material, whcu as a transplanted organ, or non-biological material such as a medical device. The membrane may be applied in a variety of ways. In one example, a membrane according to the present invention is shrink-wrapped around a pace-maker. In another example, a breast implant is spray-coated or dipped with the membrane material.

7771427, Aug 10, 2010

Dec 8, 2000

09/733302

Steven R. Cohen - La Jolla CA, US
Ralph E. Holmes - San Diego CA, US
J. Peter Amis - Carlsbad CA, US
Horst R. Fichtner - Carlsbad CA, US
Stefan M. Lemperle - La Jolla CA, US

Macropore - San Diego CA

A61B 17/00, A61F 5/04

606 57

One aspect of the present invention is a connective tissue distraction device comprising: a first transmitting structure for transmitting force to a first tissue region and a second transmitting structure for transmitting force to a second tissue region by contact with bone, and an expansion device for exerting force distracting the first transmitting structure from the second transmitting structure. At least one of the first transmitting device, the second transmitting device and the expansion structure comprises in whole or in part a biodegradable, bioerodible or bioresorbable material.

8012502, Sep 6, 2011

Nov 9, 2007

11/983562

Christopher J. Calhoun - San Diego CA, US
Ralph E. Holmes - San Diego CA, US
Kenneth K. Kleinhenz - Lakeside CA, US

MAST Biosurgery AG - Zurich

A61F 13/00, A61L 15/16, A01N 25/34

424435, 424444, 424402, 424443

Resorbable lactide polymer thin membranes are disclosed. The thin membranes are constructed of polylactide resorbable polymers, which are engineered to be absorbed into the body relatively slowly over time in order to reduce potential negative side effects. The membranes are formed to have very thin thicknesses, for example, thicknesses between about 0. 010 mm and about 0. 300 mm. The membranes can be extruded from polylactide polymers having a relatively high viscosity property, can be preshaped with relatively thick portions, and can be stored in sterile packages.

7947300, May 24, 2011

Jan 16, 2007

11/654209

Christopher J. Calhoun - San Diego CA, US
Ralph E. Holmes - San Diego CA, US
Kenneth K. Kleinhenz - Lakeside CA, US

MAST Biosurgery AG - Zurich

A61F 13/00

424422

Resorbable lactide polymer thin membranes are disclosed. The thin membranes are constructed of polylactide resorbable polymers, which are engineered to be absorbed into the body relatively slowly over time in order to reduce potential negative side effects. The membranes are formed to have very thin thicknesses, for example, thicknesses between about 0. 010 mm and about 0. 300 mm. The membranes can be extruded from polylactide polymers having a relatively high viscosity property, can be preshaped with relatively thick portions, and can be stored in sterile packages.

8048444, Nov 1, 2011

Jan 11, 2007

11/652724

Christopher J. Calhoun - Del Mar CA, US
Ralph E. Holmes - San Diego CA, US
G. Bryan Cornwall - San Diego CA, US

MAST Biosurgery AG - Zurich

A61K 9/00, A61F 2/12

424426, 623 8, 424450

An anti-adhesion membrane is placed onto an implant introduced into a surgical site of a patient to prevent post-surgical adhesions between the implant and surrounding tissue. The implant may comprise either biological material, such as a transplanted organ, or non-biological material such as a medical device. The membrane may be applied in a variety of ways. In one example, a membrane according to the present invention is shrink-wrapped around a pace-maker. In another example, a breast implant is spray-coated or dipped with the membrane material.