RALF MICHAEL LUCHE
Pilots at 196 Ct, Seattle, WA
License number
Washington A2755350
Issued Date
Feb 2017
Expiration Date
Feb 2019
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
4028 NE 196Th Ct, Seattle, WA 98155
Professional information
Dsp-4 Dual-Specificity Phosphatase
US Patent:
2003017, Sep 18, 2003
Filed:
Apr 1, 2003
Appl. No.:
10/405808
Inventors:
Ralf Luche - Seattle WA, US
Bo Wei - Kirkland WA, US
Bo Wei - Kirkland WA, US
Assignee:
Ceptyr, Inc. - Bothell WA
International Classification:
G01N033/53, G01N033/542, C12N009/16, C07K016/40
US Classification:
435/007900, 435/196000, 530/388260
Abstract:
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-4, and polypeptide variants thereof that stimulate dephosphorylation of DSP-4 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-4 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
Dsp-12 And Dsp-13 Dual-Specificity Phosphatases
US Patent:
6902919, Jun 7, 2005
Filed:
Feb 1, 2001
Appl. No.:
09/775925
Inventors:
Ralf M. Luche - Seattle WA, US
Bo Wei - Kirkland WA, US
Bo Wei - Kirkland WA, US
Assignee:
CEPTYR, Inc. - Bothell WA
International Classification:
C12N009/12, C12N001/20, C12N015/00, C07H021/04, C07K001/00
US Classification:
435194, 4352523, 4353201, 536 232, 530350
Abstract:
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatases DSP-12 and DSP-13, and polypeptide variants thereof that stimulate dephosphorylation of DSP-12 and DSP-13 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-12 and/or DSP-13 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
Dsp-12 And Dsp-13 Dual-Specificity Phosphatases
US Patent:
2005005, Mar 17, 2005
Filed:
Oct 8, 2004
Appl. No.:
10/962126
Inventors:
Ralf Luche - Seattle WA, US
Bo Wei - Kirkland WA, US
Bo Wei - Kirkland WA, US
Assignee:
CEPTYR, Inc. - Bothell WA
International Classification:
C12Q001/68, C07H021/04, A61K039/395, C12N009/16
US Classification:
424146100, 435006000, 435069100, 435196000, 435320100, 435325000, 530388260, 536023200
Abstract:
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatases DSP-12 and DSP-13, and polypeptide variants thereof, that stimulate dephosphorylation of DSP-12 and DSP-13 substrates are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-12 and/or DSP-13 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
Dsp-2 Dual-Specificity Phosphatase
US Patent:
6852520, Feb 8, 2005
Filed:
Mar 16, 2000
Appl. No.:
09/527376
Inventors:
Ralf M. Luche - Seattle WA, US
Bo Wei - Kirkland WA, US
Bo Wei - Kirkland WA, US
Assignee:
Ceptyr, Inc. - Bothell WA
International Classification:
C12N009/16, C12N001/21, C12N005/22, C12N015/52, C07H021/04
US Classification:
435196, 4352523, 4353201, 435325, 435366, 536 232
Abstract:
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-2, and polypeptide variants thereof that stimulate dephosphorylation of DSP-2 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-2 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
Dsp-5 Dual-Specificity Phosphatase
US Patent:
2005007, Apr 7, 2005
Filed:
Aug 19, 2003
Appl. No.:
10/644554
Inventors:
Ralf Luche - Seattle WA, US
Bo Wei - Kirkland WA, US
Bo Wei - Kirkland WA, US
Assignee:
CEPTYR, Inc. - Bothell WA
International Classification:
C07K016/18
US Classification:
530388250
Abstract:
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-5, and polypeptide variants thereof that stimulate dephosphorylation of DSP-5 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-5 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
Dsp-4 Dual Specificity Phosphatase
US Patent:
6841369, Jan 11, 2005
Filed:
Apr 6, 2000
Appl. No.:
09/544517
Inventors:
Ralf M. Luche - Seattle WA, US
Bo Wei - Kirkland WA, US
Bo Wei - Kirkland WA, US
Assignee:
Ceptyr, Inc. - Bothell WA
International Classification:
C12N 916, C12N 1555, C12Q 168
US Classification:
435196, 435 6, 4353201, 4352523, 536 232
Abstract:
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-4, and polypeptide variants thereof that stimulate dephosphorylation of DSP-4 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-4 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
Dsp-3 Dual-Specificity Phosphatase
US Patent:
7078210, Jul 18, 2006
Filed:
Sep 8, 2003
Appl. No.:
10/658661
Inventors:
Ralf M Luche - Seattle WA, US
Bo Wei - Kirkland WA, US
Bo Wei - Kirkland WA, US
Assignee:
CEPTYR, Inc. - Bothell WA
International Classification:
C12N 9/16, C12N 15/55
US Classification:
435196, 536 232
Abstract:
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-3, and polypeptide variants thereof that stimulate dephosphorylation of DSP-3 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-3 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
Dsp-10 Dual-Specificity Phosphatase
US Patent:
2008013, Jun 12, 2008
Filed:
Oct 2, 2007
Appl. No.:
11/866369
Inventors:
Ralf M. LUCHE - Seattle WA, US
Bo WEI - Kirkland WA, US
Bo WEI - Kirkland WA, US
Assignee:
CEPTYR, Inc. - Redmond WA
International Classification:
A61K 39/00, C07K 16/00, G01N 33/53, C12Q 1/68, C12N 5/04, A61K 38/00
US Classification:
4241391, 5303879, 435 71, 435 6, 435375, 435377, 514 12
Abstract:
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-10, and polypeptide variants thereof that stimulate dephosphorylation of DSP-10 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-10 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation, and survival.
Dsp-3 Dual-Specificity Phosphatase
US Patent:
2007012, Jun 7, 2007
Filed:
Jul 17, 2006
Appl. No.:
11/488453
Inventors:
Ralf Luche - Seattle WA, US
Bo Wei - Kirkland WA, US
Bo Wei - Kirkland WA, US
Assignee:
CEPTYR, Inc. - Bothell WA
International Classification:
A61K 39/395, C12Q 1/68, G01N 33/53, C12Q 1/34, C07H 21/04, C12P 21/06, C12N 9/16
US Classification:
424146100, 435006000, 435018000, 435069100, 435196000, 435320100, 435325000, 435007100, 530388260, 536023200
Abstract:
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-3, and polypeptide variants thereof that stimulate dephosphorylation of DSP-3 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-3 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
Dsp-10 Dual-Specificity Phosphatase
US Patent:
7279299, Oct 9, 2007
Filed:
Jul 21, 2005
Appl. No.:
11/186448
Inventors:
Ralf M. Luche - Seattle WA, US
Bo Wei - Kirkland WA, US
Bo Wei - Kirkland WA, US
Assignee:
CEPTYR, Inc. - Redmond WA
International Classification:
C12N 9/16, C12Q 9/48
US Classification:
435 15, 435196
Abstract:
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-10, and polypeptide variants thereof that stimulate dephosphorylation of DSP-10 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-10 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation, and survival.