Dr. Rakesh K Sindhi, Pittsburgh PA - MD (Doctor of Medicine)
Specialties:
General Surgery
Address:
Thomas E Starzl Transplant Inst 3459 5Th Ave, Pittsburgh 15213 (412) 648-3200 (Phone) Childrens Hospitl Pttsbrgh UPMC 4401 Penn Ave SUITE 6, Pittsburgh 15224 (412) 692-7867 (Phone)
Procedures:
Liver Transplant
Conditions:
Biliary Atresia, Liver Cancer
Certifications:
General Surgery, 2012
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
Thomas E Starzl Transplant Inst 3459 5Th Ave, Pittsburgh 15213 Childrens Hospitl Pttsbrgh UPMC 4401 Penn Ave SUITE 6, Pittsburgh 15224 Upmc Presbyterian Shadyside 200 Lothrop St, Pittsburgh 15213
Education:
Medical School Armed Forces Medical College, Maharashtra University Of Health Sciences Lincoln Hospital Tufts University New Engl Med Center University Nebr College Med
Rakesh Sindhi, Pittsburgh PA
Work:
One Children's Hospital Drive 4401 Penn Avenue 1 Penn Ave, Pittsburgh, PA 15224Children's Hospital of Pittsburgh 3705 5Th Ave, Pittsburgh, PA 15213Children's Hospital of Pittsburgh 4401 Penn Ave, Pittsburgh, PA 15224
Antigen Presenting Cell Assay
US Patent:
2014005, Feb 27, 2014
Filed:
Oct 11, 2013
Appl. No.:
14/052391
Inventors:
Rakesh Sindhi - Pittsburgh PA, US Chethan AshokKumar - Pittsburgh PA, US
Assignee:
University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
G01N 33/50
US Classification:
435 34
Abstract:
Disclosed herein are methods for diagnosing or predicting acute cellular and/or humoral rejection in a subject. In one example, a method of assessing organ rejection includes contacting a first sample comprising antigen presenting cells (APCs) obtained from a subject in need of or having received an organ transplant with a donor antigen from a donor under conditions sufficient to induce uptake of the donor antigen; contacting a second sample comprising APCs obtained from the subject in need of or having received an organ transplant with a third-party antigen under conditions sufficient to induce uptake of the third-party antigen; and determining an antigen presenting index by determining a ratio of uptake of the donor antigen in the first sample to uptake of the third-party antigen in the second sample, wherein the ratio of greater than one indicates organ rejection and the APCs are monocytes or monocyte-derived cells.
Multiparameteric Method For Assessing Immune System Status
US Patent:
2006027, Dec 7, 2006
Filed:
Jun 5, 2006
Appl. No.:
11/447213
Inventors:
Rakesh Sindhi - Pittsburgh PA, US
Assignee:
University of Pittsburgh of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
C12Q 1/70, G01N 33/567, G01N 33/554, G01N 33/53
US Classification:
435005000, 435007200, 435007320
Abstract:
The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a third party sample and combines the assessments of the multiple parameters to correlate the test reaction with a clinical event.
Multiparametric Method For Assessing Immune System Status
US Patent:
2013021, Aug 22, 2013
Filed:
Mar 19, 2013
Appl. No.:
13/847252
Inventors:
University of Pittsburgh - Of the Commonwealth System of Higher Education - , US Rakesh Sindhi - Pittsburgh PA, US
Assignee:
University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
G01N 33/569
US Classification:
435 724
Abstract:
The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a third party sample and combines the assessments of the multiple parameters to correlate the test reaction with a clinical event.
B-Cell Antigen Presenting Cell Assay
US Patent:
2013002, Jan 31, 2013
Filed:
Apr 8, 2011
Appl. No.:
13/639428
Inventors:
Rakesh Sindhi - Pittsburgh PA, US Chethan Ashokkumar - Pittsburgh PA, US
International Classification:
C12Q 1/04, G01N 21/64
US Classification:
435 34
Abstract:
Disclosed herein are methods for diagnosing or predicting B-cell rejection in a subject. In one example, for assessing transplant rejection, the method includes determining an antigen presenting index by comparing uptake of a donor antigen to uptake of a reference antigen in a biological sample obtained from the subject. In another example, for assessing GVHD, the method includes determining an antigen presenting index by comparing uptake of a recipient antigen to uptake of a reference antigen in a biological sample obtained from the subject.