RAJIV DHIR
Medical Practice in Seven Fields, PA
License number
Pennsylvania MD063267L
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Seven Fields, PA 16046
Professional information
Method Of Determining The Prognosis Of Human Cancer
US Patent:
2008004, Feb 21, 2008
Filed:
Apr 19, 2007
Appl. No.:
11/737573
Inventors:
Uddhav Kelavkar - Wexford PA, US
Rajiv Dhir - Mars PA, US
Denise O'Keefe - Wexford PA, US
Rajiv Dhir - Mars PA, US
Denise O'Keefe - Wexford PA, US
Assignee:
University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
C12Q 1/68
US Classification:
435006000
Abstract:
The invention provides methods and kits of diagnosing or determining the prognosis of a cancer in a mammal comprising determining the methylation status of the (15)-Lipoxygenase type 1 (15-LO-1) promoter in the mammal's tissue, specifically, the methylation status of the 10th CpG dinucleotide of the 15-LO-1 promoter as defined by nucleotides 727-728 of SEQ ID NO:1 in the tissue sample. The methods can include detecting the methylation status of DNA in a tissue sample, or by measuring the expression level of 15-LO-1 protein or mRNA.