Inventors:
Nancy Klauber DeMore - Durham NC, US
Cam Patterson - Chapel Hill NC, US
Rajendra Bhati - Tampa FL, US
Bradley G. Bone - Apex NC, US
International Classification:
A61K 39/395, A61K 31/7088, A61K 38/02, C07K 16/18, A61P 43/00
US Classification:
4241301, 514 44 R, 514 133, 5303881, 5303879, 5303873
Abstract:
The present invention relates to the identification of polynucleotides and polypeptides having increased expression in tumor blood vessels. The invention further relates to the use of the identified polynucleotides and polypeptides, and inhibitors of the polynucleotides and polypeptides, in the regulation of angiogenesis and the diagnosis and treatment of angiogenesis-related diseases such as cancer.