Inventors:
C. Shad Thaxton - Chicago IL, US
Chad A. Mirkin - Wilmette IL, US
Kaylin M. McMahon - Chicago IL, US
Sushant Tripathy - Evanston, IL
Raja Kannan Mutharasan - Chicago IL, US
David M. Leander - St. Louis MO, US
Andrea Luthi - Evanston IL, US
Assignee:
NORTHWESTERN UNIVERSITY - Evanston IL
International Classification:
A61K 9/127, A61K 31/7088, A61K 31/713, C12N 5/09, A61P 35/00, A61P 29/00, A61P 3/06, A61P 25/28, A61P 25/00, A61P 25/16, A61K 9/00, A61P 9/10, B82Y 5/00
US Classification:
424450, 424400, 514 44 A, 435375, 977800, 977773, 977907, 977915
Abstract:
Articles, compositions, kits, and methods relating to nanostructures, including synthetic nanostructures, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanostructure core may be surrounded by a shell including a material, such as a lipid bilayer, and may include other components such as oligonucleotides. In some embodiments, the structures, when introduced into a subject, can be used to deliver nucleic acids and/or can regulate gene expression. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions. In some cases, the structures are both a therapeutic agent and a diagnostic agent.