DR. RAJ R MAKKAR, M.D.
Medical Practice in Los Angeles, CA

2008031, Dec 18, 2008

Apr 25, 2008

12/150329

Jay N. Schapira - Beverly Hills CA, US
Raj Makkar - Los Angeles CA, US

A61F 2/04, A61K 9/00, A61K 39/395

424423, 424486, 424488, 4241731, 977906

A biologically engineered construct comprising of a polymeric biomatrix, designed with a nanophase texture, and a therapeutic agent for the purpose of tissue regeneration and/or controlled delivery of regenerative factors and therapeutic substances after it is implanted into tissues, vessels, or luminal structures within the body. The therapeutic agent may be a therapeutic substance or a biological agent, such as antibodies, ligands, or living cells. The nanophase construct is designed to maximize lumen size, promote tissue remodeling, and ultimately make the implant more biologically compatible. The nano-textured polymeric biomatrix may comprise one or more layers containing therapeutic substances and/or beneficial biological agents for the purpose of controlled, differential substance/drug delivery into the luminal and abluminal surfaces of the vessel or lumen, and the attraction of target molecules/cells that will regenerate functional tissue. The topographic and biocompatible features of this layered biological construct provides an optimal environment for tissue regeneration along with a programmed-release, drug delivery system to improve physiological tolerance of the implant, and to maximize the cellular survival, migration, and integration within the implanted tissues.

2011030, Dec 8, 2011

Nov 19, 2009

13/130560

Anthony J White - Melbourne, AU
Raj R Makkar - Los Angeles CA, US
Eduardo Marbán - Beverly Hills CA, US

CEDARS-SINAI MEDICAL CENTER - Los Angeles CA

A61K 35/34, A61P 9/04, A61P 9/10, C12N 5/071, A61P 9/00

424 937, 435377, 435325

Presented herein, generally, are methods for generating reprogrammed mammalian cells, e.g., induced pluripotent stem cells, from differentiated mammalian cells without the use of viral or plasmid vectors. In one aspect, the methods involve contacting a differentiated cell with transducible polypeptides comprising a reprogramming factor polypeptide linked to a cell penetration peptide so that a reprogrammed mammalian cell that exhibits at least one characteristic of pluripotency is generated. Also presented herein are methods for cardiac differentiation of a mammalian cell without the use of viral or plasmid vectors. In one aspect, such methods involve contacting a mammalian cell exhibiting at least one characteristic of pluripotency with a transducible polypeptide, so that cardiac differentiation of the cell occurs.

2011026, Nov 3, 2011

Jun 15, 2011

13/161459

Jay N. Schapira - Beverly Hills CA, US
Raj Makkar - Los Angeles CA, US

A61K 9/00, B82Y 5/00

424400, 977906

A biologically engineered construct comprising of a polymeric biomatrix, designed with a nanophase texture, and a therapeutic agent for the purpose of tissue regeneration and/or controlled delivery of regenerative factors and therapeutic substances after it is implanted into tissues, vessels, or luminal structures within the body. The therapeutic agent may be a therapeutic substance or a biological agent, such as antibodies, ligands, or living cells. The nanophase construct is designed to maximize lumen size, promote tissue remodeling, and ultimately make the implant more biologically compatible. The nano-textured polymeric biomatrix may comprise one or more layers containing therapeutic substances and/or beneficial biological agents for the purpose of controlled, physiological, differential substance/drug delivery into the luminal and abluminal surfaces of the vessel or lumen, and the attraction of target molecules/cells that will regenerate functional tissue. The topographic and biocompatible features of this layered biological construct provides an optimal environment for tissue regeneration along with a programmed-release, drug delivery system to improve physiological tolerance of the implant, and to maximize the cellular survival, migration, and integration within the implanted tissues.

2011028, Nov 17, 2011

Jan 15, 2010

13/144881

James S. Forrester - Malibu CA, US
Raj R. Makkar - Los Angeles CA, US
Eduardo Marbán - Beverly Hills CA, US

CEDARS-SINAI MEDICAL CENTER - Los Angeles CA

A61K 35/12, A61P 9/00, A61K 38/18, A61K 38/00

424 931, 514 164, 514 89

Methods for treating an injured cardiac tissue in a subject are provided herein. Methods for improving survival, engraftment and proliferation of stem cells in a cardiac tissue are provided. Also provided are methods for generating cardiac cells. Further provided are compositions for generating cardiac cells in a subject.