DR. RAJ R MAKKAR, M.D.
Medical Practice in Los Angeles, CA
License number
California A51958
Category
Medical Practice
Type
Specialist
Address
Address
8700 Wilshire Blvd., Los Angeles, CA 90048
Phone
(310) 967-1884
(310) 967-1744 (Fax)
(310) 967-1744 (Fax)
Personal information
See more information about RAJ R MAKKAR at radaris.comName
Address
Phone
2183 Sunset Plaza Dr, West Hollywood, CA 90069
Professional information
Dr. Raj Makkar, Los Angeles CA - MD (Doctor of Medicine)
Specialties:
Cardiology, Interventional Cardiology
Address:
8631 W 3Rd St SUITE 415E, Los Angeles 90048
(310) 423-3977 (Phone)
(310) 423-3977 (Phone)
Certifications:
Cardiovascular Disease, 1997, Internal Medicine, 1992, Interventional Cardiology, 1999
Awards:
Healthgrades Honor Roll
Languages:
English, Hindi
Hospitals:
8631 W 3Rd St SUITE 415E, Los Angeles 90048
Cedars - Sinai Medical Center
8700 West Beverly Blvd, West Hollywood 90048
Cedars - Sinai Medical Center
8700 West Beverly Blvd, West Hollywood 90048
Education:
Medical School
Bj Medical College, Ahmedabad, Gujarat University
Graduated: 1990
Bj Medical College, Ahmedabad, Gujarat University
Graduated: 1990
Raj R Makkar, Los Angeles CA
Specialties:
Internal Medicine, Cardiovascular Disease, Cardiology
Work:
Cedars-Sinai Medical Center
8631 W 3Rd St, Los Angeles, CA 90048
8631 W 3Rd St, Los Angeles, CA 90048
Education:
Kakatiya Medical College Ina39, Wayne State University School (1990)
Raj Raghunath Makkar, West Hollywood CA
Specialties:
Cardiologist
Address:
8700 Beverly Blvd, West Hollywood, CA 90048
Programmed-Release, Nanostructured Biological Construct
US Patent:
2008031, Dec 18, 2008
Filed:
Apr 25, 2008
Appl. No.:
12/150329
Inventors:
Jay N. Schapira - Beverly Hills CA, US
Raj Makkar - Los Angeles CA, US
Raj Makkar - Los Angeles CA, US
International Classification:
A61F 2/04, A61K 9/00, A61K 39/395
US Classification:
424423, 424486, 424488, 4241731, 977906
Abstract:
A biologically engineered construct comprising of a polymeric biomatrix, designed with a nanophase texture, and a therapeutic agent for the purpose of tissue regeneration and/or controlled delivery of regenerative factors and therapeutic substances after it is implanted into tissues, vessels, or luminal structures within the body. The therapeutic agent may be a therapeutic substance or a biological agent, such as antibodies, ligands, or living cells. The nanophase construct is designed to maximize lumen size, promote tissue remodeling, and ultimately make the implant more biologically compatible. The nano-textured polymeric biomatrix may comprise one or more layers containing therapeutic substances and/or beneficial biological agents for the purpose of controlled, differential substance/drug delivery into the luminal and abluminal surfaces of the vessel or lumen, and the attraction of target molecules/cells that will regenerate functional tissue. The topographic and biocompatible features of this layered biological construct provides an optimal environment for tissue regeneration along with a programmed-release, drug delivery system to improve physiological tolerance of the implant, and to maximize the cellular survival, migration, and integration within the implanted tissues.
Generation Of Induced Pluripotent Stem Cells Without The Use Of Viral Vectors
US Patent:
2011030, Dec 8, 2011
Filed:
Nov 19, 2009
Appl. No.:
13/130560
Inventors:
Anthony J White - Melbourne, AU
Raj R Makkar - Los Angeles CA, US
Eduardo Marbán - Beverly Hills CA, US
Raj R Makkar - Los Angeles CA, US
Eduardo Marbán - Beverly Hills CA, US
Assignee:
CEDARS-SINAI MEDICAL CENTER - Los Angeles CA
International Classification:
A61K 35/34, A61P 9/04, A61P 9/10, C12N 5/071, A61P 9/00
US Classification:
424 937, 435377, 435325
Abstract:
Presented herein, generally, are methods for generating reprogrammed mammalian cells, e.g., induced pluripotent stem cells, from differentiated mammalian cells without the use of viral or plasmid vectors. In one aspect, the methods involve contacting a differentiated cell with transducible polypeptides comprising a reprogramming factor polypeptide linked to a cell penetration peptide so that a reprogrammed mammalian cell that exhibits at least one characteristic of pluripotency is generated. Also presented herein are methods for cardiac differentiation of a mammalian cell without the use of viral or plasmid vectors. In one aspect, such methods involve contacting a mammalian cell exhibiting at least one characteristic of pluripotency with a transducible polypeptide, so that cardiac differentiation of the cell occurs.
Programmed-Release, Nanostructured Biological Construct For Stimulating Cellular Engraftment For Tissue Regeneration
US Patent:
2011026, Nov 3, 2011
Filed:
Jun 15, 2011
Appl. No.:
13/161459
Inventors:
Jay N. Schapira - Beverly Hills CA, US
Raj Makkar - Los Angeles CA, US
Raj Makkar - Los Angeles CA, US
International Classification:
A61K 9/00, B82Y 5/00
US Classification:
424400, 977906
Abstract:
A biologically engineered construct comprising of a polymeric biomatrix, designed with a nanophase texture, and a therapeutic agent for the purpose of tissue regeneration and/or controlled delivery of regenerative factors and therapeutic substances after it is implanted into tissues, vessels, or luminal structures within the body. The therapeutic agent may be a therapeutic substance or a biological agent, such as antibodies, ligands, or living cells. The nanophase construct is designed to maximize lumen size, promote tissue remodeling, and ultimately make the implant more biologically compatible. The nano-textured polymeric biomatrix may comprise one or more layers containing therapeutic substances and/or beneficial biological agents for the purpose of controlled, physiological, differential substance/drug delivery into the luminal and abluminal surfaces of the vessel or lumen, and the attraction of target molecules/cells that will regenerate functional tissue. The topographic and biocompatible features of this layered biological construct provides an optimal environment for tissue regeneration along with a programmed-release, drug delivery system to improve physiological tolerance of the implant, and to maximize the cellular survival, migration, and integration within the implanted tissues.
Methods And Compositions For Cardiac Tissue Regeneration
US Patent:
2011028, Nov 17, 2011
Filed:
Jan 15, 2010
Appl. No.:
13/144881
Inventors:
James S. Forrester - Malibu CA, US
Raj R. Makkar - Los Angeles CA, US
Eduardo Marbán - Beverly Hills CA, US
Raj R. Makkar - Los Angeles CA, US
Eduardo Marbán - Beverly Hills CA, US
Assignee:
CEDARS-SINAI MEDICAL CENTER - Los Angeles CA
International Classification:
A61K 35/12, A61P 9/00, A61K 38/18, A61K 38/00
US Classification:
424 931, 514 164, 514 89
Abstract:
Methods for treating an injured cardiac tissue in a subject are provided herein. Methods for improving survival, engraftment and proliferation of stem cells in a cardiac tissue are provided. Also provided are methods for generating cardiac cells. Further provided are compositions for generating cardiac cells in a subject.