Inventors:
Rahul K. Nath - Houston TX, US
Usha Nath - Houston TX, US
International Classification:
A61K 31/70, C07H 21/02, C07H 21/04, C12Q 1/68
US Classification:
514 44A, 435375, 435377, 536 231, 536 241, 536 245
Abstract:
The invention provides, in the treatment of malignant tumors, antisense DNA oligonucleotides which are effective in inhibiting the expression of a wild type COL1A1 gene, in combination with a chemotherapy drug, typically bleomycin, cyclophosphamide, or methotrexate, which otherwise is known to cause lung disease such as pulmonary fibrosis.