DR. RABIH O DAROUICHE, M.D.
Osteopathic Medicine at Holcombe Blvd, Houston, TX

6589591, Jul 8, 2003

Jul 10, 2001

09/902127

Mohammad David Mansouri - Houston TX
Rabih O. Darouiche - Houston TX

Baylor College of Medicine - Houston TX

A61L 2700

427 224, 427 228, 427 23, 427 231, 427 225, 427336, 427348, 4273722, 4274301

A non-metallic medical device treated with a antimicrobial agents is provided. Different combinations of antimicrobial agents can be used for different types of non-metallic medical devices depending on the types of infections related to each device. The combination of different antimicrobial substances has a synergistic effect against certain bacteria and fungi. An antimicrobial agent can be used to treat a non-metallic medical device by mixing the antimicrobial agent with an acid solution and glycerol and exposing the non-metallic medical device to the resulting mixture such that an enough of the antimicrobial agent binds to a portion of the non-metallic medical device to inhibit the growth of bacterial and fungal organisms.

2003022, Dec 11, 2003

Jun 17, 2003

10/463062

Mohammad Mansouri - Houston TX, US
Rabih Darouiche - Houston TX, US

B05D001/18, A61L002/00, A61F002/04

623/023710, 427/002100, 427/430100

A non-metallic medical device treated with a antimicrobial agents is provided. Different combinations of antimicrobial agents can be used for different types of non-metallic medical devices depending on the types of infections related to each device. The combination of different antimicrobial substances has a synergistic effect against certain bacteria and fungi. An antimicrobial agent can be used to treat a non-metallic medical device by mixing the antimicrobial agent with an acid solution and glycerol and exposing the non-metallic medical device to the resulting mixture such that an enough of the antimicrobial agent binds to a portion of the non-metallic medical device to inhibit the growth of bacterial and fungal organisms.

6719991, Apr 13, 2004

Jun 8, 2001

09/877898

Rabih O. Darouiche - Houston TX
Richard Hull - Houston TX

Baylor College of Medicine - Houston TX

A61F 1300

424422, 424423, 4241841, 427 23, 427 221, 427 225, 427 21, 427 28, 427 228, 422 1, 422 44, 623 12, 623 1, 623 2, 623 18, 604264, 604265

This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of said medical device, an antimicrobial coating layer and a non-pathogenic bacterial coating layer, wherein the antimicrobial and non-pathogenic bacterial coating layers inhibit the growth of pathogenic bacterial and fungal organisms. The non-pathogenic bacterium used in the bacterial coating layer is resistant to the antimicrobial agent. Furthermore, the non-pathogenic bacterium layer includes at least one of the following: viable whole cells, non-viable whole cells, or cellular structures or extracts. The antimicrobial agent and non-pathogenic bacterium are used to develop a kit comprising these compositions in one container or in separate containers. The kit is used to coat a catheter prior to implantation in a mammal.

6558686, May 6, 2003

Nov 8, 1995

08/555198

Rabih O. Darouiche - Houston TX

Baylor College of Medicine - Houston TX

A01N 2510

424423, 523122, 600 30, 6048911, 623 9

A medical device of metallic or non-metallic material coated with a combination of antiseptics and a method for coating such an implant with a combination of antiseptics is provided. Different combinations of antiseptics can be used for different types of medical devices depending on the spectrum of organisms that cause the infections related to each device. The combination of different antiseptics has a synergistic effect against certain bacteria and fungi. The combination of antiseptic can be applied to the surface of a metallic device by dissolving the combination of antiseptics and a polymeric sticking agent in an acid solution to form an antiseptic solution, and applying the antiseptic solution, in an effective concentration to inhibit the growth of bacterial and fungal organisms, to at least a portion of the surfaces of the medical device. The antiseptic combination can be applied to the surface of and impregnate the material of a non-metallic implant by forming an antiseptic composition by dissolving the combination of antiseptics in an organic solvent and adding a penetrating agent to the composition, and applying the antiseptic composition to at least a portion of the medical implant under conditions where the antiseptic composition permeates the material of the medical implant.

5853745, Dec 29, 1998

Mar 26, 1997

8/824596

Rabih O. Darouiche - Houston TX

Baylor College of Medicine - Houston TX

A61F 200, A61F 202, A61M 2500

424423

A medical implant, such as an orthopedic implant, having a first antimicrobial coating layer and a second protective layer, and a method for coating such an implant is provided. The medical implant has one or more of its surfaces coated with an antimicrobial coating layer and a protective coating layer formed over the antimicrobial coating layer. The protective coating layer includes a durable coating layer composed of material such as collodion and nylon, and a resilient coating layer composed of material such as collodion. The coating layers are applied by applying an antimicrobial coating layer to at least a portion of the surfaces of the medical implant, applying a durable coating layer over the antimicrobial coating layer, and applying a resilient coating layer over the durable coating layer.

2007009, Apr 26, 2007

Oct 25, 2006

11/586407

Rabih Darouiche - Houston TX, US

Baylor College of Medicine - Houston TX
Gov. of the USA As Represented by the Secretary of the Dept. of Health and Human Services - Rockville MD

A61F 2/02, A61L 33/00, B05D 3/00

623011110, 427002100, 427002240, 604265000

This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of the medical device, a bactericidal coating layer, wherein the bactericidal coating layer comprises a bactericidal agent; and applying to at least a portion of the surface of the medical device, a bacteriostatic coating, wherein the bacteriostatic coating layer comprises a bacteriostatic agent wherein the combination of the bactericidal and bacteriostatic agents are in an effective concentration to inhibit growth of microbial organisms relative to an uncoated medical device. The two antimicrobial agents are used to develop a kit comprising these compositions in one container or in separate containers. The kit is used to coat or flush medical devices prior to or after implantation in a mammal.

2004016, Aug 26, 2004

Feb 26, 2004

10/787627

Rabih Darouiche - Houston TX, US
Richard Hull - Houston TX, US

A61K045/00, B05D003/00

424/093450, 427/002240

This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of said medical device, an antimicrobial coating layer and a non-pathogenic bacterial coating layer, wherein the antimicrobial and non-pathogenic bacterial coating layers inhibit the growth of pathogenic bacterial and fungal organisms. The non-pathogenic bacterium used in the bacterial coating layer is resistant to the antimicrobial agent. Furthermore, the non-pathogenic bacterium layer includes at least one of the following: viable whole cells, non-viable whole cells, or cellular structures or extracts. The antimicrobial agent and non-pathogenic bacterium are used to develop a kit comprising these compositions in one container or in separate containers. The kit is used to coat a catheter prior to implantation in a mammal.

5217493, Jun 8, 1993

Mar 11, 1992

7/850197

Issam I. Raad - Houston TX
Rabih O. Darouiche - Houston TX

Board of Regents, The University of Texas System - Austin TX

A61F 202

623 11

An implantable medical device having long lasting resistance to staphylococcal biofilm colonization is provided. Implantable medical devices such as catheters, shunts, prosthesis, pacemakers, etc. are susceptible to colonization by biofilm adherent microorganisms, especially staphylococci. While systemic staphylococcal infections are effectively treated by many antibiotics, vancomycin being the antibiotic of choice, this same bacteria when encased in biofilm adhering to indwelling medical devices is generally resistant to antibiotic treatment. By the present invention, the combination of rifampin and minocycline or the combination of rifampin and novobiocin when coated on the surfaces of implantable medical devices unexpectedly provides superior antibacterial activity against staphylococcal biofilm colonization on the coated surface of indwelling medical devices.

7238363, Jul 3, 2007

Mar 31, 2005

11/095975

Mohammad D. Mansouri - Houston TX, US
Rabih O. Darouiche - Houston TX, US

Baylor College of Medicine - Houston TX

A61F 2/00, A61L 33/00

424423, 427 224

The incorporation of one or more therapeutic agents on metallic and non-metallic medical prostheses is provided. The therapeutic agent can be used, for example, to prevent, treat, or reduce bacterial and fungal infections associated with these implants. Additionally, the therapeutic agents can be used to effect other therapeutic benefits. Specifically, a bilayer therapeutic coating is applied in two steps. Additionally, non-antimicrobial therapeutic agents may be incorporated in this coating to treat, prevent, modify, or stimulate certain clinical bioactivities.