QIUYAN ZHAO
Broker in Southborough, MA
License number
Massachusetts 9503294
Issued Date
Apr 5, 2007
Expiration Date
Jul 5, 2017
Type
Salesperson
Address
Address
Southborough, MA 01772
Personal information
See more information about QIUYAN ZHAO at radaris.comName
Address
Phone
11 Southwood Dr, Southborough, MA 01772
11 Wood Dr, Southborough, MA 01772
Professional information
Oligonucleotide Mediated Specific Cytokine Induction And Prophylaxis And Treatment Of Viral Infection In A Mammal
US Patent:
7700570, Apr 20, 2010
Filed:
Jun 12, 2002
Appl. No.:
10/167825
Inventors:
Sudhir Agrawal - Shrewsbury MA, US
Qiuyan Zhao - Southboro MA, US
Qiuyan Zhao - Southboro MA, US
Assignee:
Idera Pharmaceuticals, Inc. - Cambridge MA
International Classification:
A01N 43/04, C07H 21/02, C07H 21/04
US Classification:
514 44, 536 231, 536 242, 536 2433
Abstract:
The invention provides new methods for modulating specific CMI-inducing cytokines in vivo. Such new methods result in stimulation of the cytokines IL-6, IL-12 MIP-1β and MCP without substantially inducing undesired cytokines. The methods according to the invention are based upon administration of oligonucleotides containing particular structural motifs which lead to specific cytokine induction.
Immunostimulatory Activity Of Cpg Oligonucleotides Containing Non-Ionic Methylphosophonate Linkages
US Patent:
2003012, Jul 10, 2003
Filed:
Aug 12, 2002
Appl. No.:
10/137687
Inventors:
Dong Yu - Westboro MA, US
Ekambar Kandimalla - Southboro MA, US
Qiuyan Zhao - Southboro MA, US
Sudhir Agrawal - Shrewsbury MA, US
Ekambar Kandimalla - Southboro MA, US
Qiuyan Zhao - Southboro MA, US
Sudhir Agrawal - Shrewsbury MA, US
International Classification:
A61K048/00, C12Q001/68
US Classification:
435/006000, 514/044000
Abstract:
Bacterial DNA and synthetic oligodeoxynucleotides containing unmethylated CpG-motifs in a particular sequence context activate vertebrate immune cells. We examined the significance of negatively charged internucleoside linkages in the flanking sequences 5′ and 3′ to the CpG-motif on immunostimulatory activity. Cell proliferation and secretion of IL-12 and IL-6 in mouse spleen cell cultures, and spleen weights of mice increased significantly when a non-ionic linkage was placed at least four or more internucleoside linkages away from the CpG-motif in the 5′-flanking sequence. When the non-ionic linkage was placed closer than three internucleoside linkages in the 5′-flanking sequence to the CpG-motif, immunostimulatory activity was suppressed compared with that observed with the unmodified parent oligo. In general, the placement of non-ionic linkage in the 3′-flanking sequence to the CpG-motif either did not affect or slightly increased immunostimulatory activity compared with the parent oligo. These results have significance in understanding CpG oligonucleotide-receptor interactions and the development of potent immunomodulatory agents.
Modulation Of Immunostimulatory Activity Of Immunostimulatory Oligonucleotide Analogs By Positional Chemical Changes
US Patent:
7824696, Nov 2, 2010
Filed:
Oct 27, 2003
Appl. No.:
10/694418
Inventors:
Ekambar R. Kandimalla - Southboro MA, US
Qiuyan Zhao - Southboro MA, US
Dong Yu - Westboro MA, US
Sudhir Agrawal - Shrewsbury MA, US
Qiuyan Zhao - Southboro MA, US
Dong Yu - Westboro MA, US
Sudhir Agrawal - Shrewsbury MA, US
Assignee:
Idera Pharmaceuticals, Inc. - Cambridge MA
International Classification:
A61K 47/00
US Classification:
4242781
Abstract:
The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds.
Modulation Of Immunostimulatory Activity Of Immunostimulatory Oligonucleotide Analogs By Positional Chemical Changes
US Patent:
8030462, Oct 4, 2011
Filed:
Oct 27, 2003
Appl. No.:
10/694383
Inventors:
Ekambar R. Kandimalla - Southboro MA, US
Qiuyan Zhao - Southboro MA, US
Dong Yu - Westboro MA, US
Sudhir Agrawal - Shrewsbury MA, US
Qiuyan Zhao - Southboro MA, US
Dong Yu - Westboro MA, US
Sudhir Agrawal - Shrewsbury MA, US
Assignee:
Idera Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07H 21/00
US Classification:
536 231, 4241841, 4242781
Abstract:
The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds.
Modulation Of Immunostimulatory Activity Of Immunostimulatory Oligonucleotide Analogs By Positional Chemical Changes
US Patent:
7932367, Apr 26, 2011
Filed:
Oct 27, 2003
Appl. No.:
10/694586
Inventors:
Ekambar R. Kandimalla - Southboro MA, US
Qiuyan Zhao - Southboro MA, US
Dong Yu - Westboro MA, US
Sudhir Agrawal - Shrewsbury MA, US
Qiuyan Zhao - Southboro MA, US
Dong Yu - Westboro MA, US
Sudhir Agrawal - Shrewsbury MA, US
Assignee:
Idera Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07H 21/00
US Classification:
536 231, 4241841, 4242781
Abstract:
The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds.
Modulation Of Immunostimulatory Activity Of Immunostimulatory Oligonucleotide Analogs By Positional Chemical Changes
US Patent:
7833538, Nov 16, 2010
Filed:
Nov 9, 2005
Appl. No.:
11/270805
Inventors:
Ekambar R. Kandimalla - Southboro MA, US
Qiuyan Zhao - Southboro MA, US
Dong Yu - Westboro MA, US
Sudhir Agrawal - Shrewsbury MA, US
Qiuyan Zhao - Southboro MA, US
Dong Yu - Westboro MA, US
Sudhir Agrawal - Shrewsbury MA, US
Assignee:
Idera Pharmaceuticals, Inc. - Cambridge MA
International Classification:
A61K 47/00
US Classification:
4242781
Abstract:
The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds.
Modulation Of Immunostimulatory Activity Of Immunostimulatory Oligonucleotide Analogs By Positional Chemical Changes
US Patent:
2004026, Dec 30, 2004
Filed:
Oct 27, 2003
Appl. No.:
10/694075
Inventors:
Ekambar Kandimalla - Southboro MA, US
Qiuyan Zhao - Southboro MA, US
Dong Yu - Westboro MA, US
Sudhir Agrawal - Shrewsbury MA, US
Qiuyan Zhao - Southboro MA, US
Dong Yu - Westboro MA, US
Sudhir Agrawal - Shrewsbury MA, US
International Classification:
A61K048/00, C07H021/02
US Classification:
514/044000, 536/023100
Abstract:
The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds.
Modulation Of Immunostimulatory Activity Of Immunostimulatory Oligonucleotide Analogs By Positional Chemical Changes
US Patent:
7790168, Sep 7, 2010
Filed:
Oct 27, 2003
Appl. No.:
10/694207
Inventors:
Ekambar R. Kandimalla - Southboro MA, US
Qiuyan Zhao - Southboro MA, US
Dong Yu - Westboro MA, US
Sudhir Agrawal - Shrewsbury MA, US
Qiuyan Zhao - Southboro MA, US
Dong Yu - Westboro MA, US
Sudhir Agrawal - Shrewsbury MA, US
Assignee:
Idera Pharmaceuticals, Inc - Cambridge MA
International Classification:
A61K 39/00, A61K 39/385, A01N 43/04, C07H 21/02
US Classification:
4241841, 4241931, 4242781, 514 44, 536 231
Abstract:
The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds.
Modulation Of Immunostimulatory Activity Of Immunostimulatory Oligonucleotide Analogs By Positional Chemical Changes
US Patent:
7262286, Aug 28, 2007
Filed:
Sep 26, 2001
Appl. No.:
09/965116
Inventors:
Ekambar R. Kandimalla - Southboro MA, US
Qiuyan Zhao - Southboro MA, US
Dong Yu - Westboro MA, US
Sudhir Agrawal - Shrewsbury MA, US
Qiuyan Zhao - Southboro MA, US
Dong Yu - Westboro MA, US
Sudhir Agrawal - Shrewsbury MA, US
Assignee:
Idera Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07H 21/00
US Classification:
536 231, 4241841, 4242781, 514 2, 514 7
Abstract:
The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds.
Modulation Of Immunostimulatory Activity Of Immunostimulatory Oligonucleotide Analogs By Positional Chemical Changes
US Patent:
8476416, Jul 2, 2013
Filed:
Dec 12, 2006
Appl. No.:
11/637184
Inventors:
Ekambar R. Kandimalla - Southboro MA, US
Qiuyan Zhao - Southboro MA, US
Dong Yu - Westboro MA, US
Sudhir Agrawal - Shrewsbury MA, US
Qiuyan Zhao - Southboro MA, US
Dong Yu - Westboro MA, US
Sudhir Agrawal - Shrewsbury MA, US
Assignee:
Idera Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07H 21/00
US Classification:
536 231, 4241841, 4242781
Abstract:
The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds.