Inventors:
Joseph Kovacs - Potomac MD, US
Shengning Huang - N. Potomac MD, US
Henry Masur - Bethesda MD, US
Steven Fischer - Rockville MD, US
Vee Gill - Potomac MD, US
Qin Mei - North Wales PA, US
Assignee:
The Government of the USA represented by Secretary of the Department of Health & Human Services
International Classification:
C12Q001/68, C07H021/04, C07K014/195
US Classification:
435/006000, 435/069300, 435/320100, 435/252300, 530/395000, 536/023700
Abstract:
Particularly sensitive techniques for the detection of in clinical samples are disclosed. These techniques relate to the PCR amplification and/or detection of human-major surface glycoprotein (MSG) gene sequences. Also disclosed are seven novel genes encoding human-MSG, and the proteins encoded for by these genes. These genes provide proof that human-MSG is encoded for by a highly conserved gene family, and that the corresponding proteins have a very highly conserved region of about 100 amino acids near their C-terminal end. This highly conserved carboxy-terminal region has a significantly different sequence than that found in rat-derived MSG.