Inventors:
Paras Prasad - Williamsville NY, US
Earl Bergey - South Dayton NY, US
Purnendu Dutta - Williamsville NY, US
Dhruba Bharali - Amherst NY, US
Michal Stachowiak - East Amherst NY, US
Tymish Ohulchanskyy - Kenmore NY, US
Ilona Klejbor - Gdynia, PL
Indrajit Roy - Amherst NY, US
International Classification:
A61K 48/00, A61K 9/50, A61K 9/16, C12N 15/87
US Classification:
424490000, 514044000, 435459000, 977916000
Abstract:
Provided are amino functionalized ORMOSIL nanoparticles. Also provided are compositions comprising such particles and compositions in which the nanoparticles are complexed to polynucleotides. The complexing of polynucleotides to the amino functionalized ORMOSIL nanoparticles protects the polynucleotides from environmental damage. These complexes can be used for delivery of polynucleotides to cells.