Inventors:
Pradeep K. Singh - Iowa City IA, US
Michael J. Welsh - Riverside IA, US
Everett P. Greenberg - Iowa City IA, US
International Classification:
A61K 38/00, A61K 39/40
US Classification:
514 2, 514 6, 514 12, 530367, 530400, 435 72, 424 91
Abstract:
The invention presented herein provides methods and compositions for the prevention and treatment of bacterial infections. The methods are based on the discovery that depletion of bioavailable iron stimulates surface motility in bacteria thus inhibiting the ability of a bacterial population to develop into a biofilm.